Department of Psychiatry and Mental Health, University of Cape Town (UCT), Cape Town, South Africa.
ACSENT Laboratory, Department of Psychology, University of Cape Town (UCT), Cape Town, South Africa.
AIDS Care. 2022 Feb;34(2):227-231. doi: 10.1080/09540121.2021.1891191. Epub 2021 Feb 24.
HIV-associated functional impairment may cause cognitive impairment secondary to the viral infection, hence, associations between cognitive impairment and functional impairment in youth living with HIV are important to assess. We sought to determine whether cognitive impairment is associated with functional impairment and if it carries higher risk for also having functional impairment. We collected parent-rated information regarding youth functional impairment on four different measures and administered a cognitive battery to youth to determine cognitive impairment, 203 HIV-infected youth and 44 HIV-uninfected controls. Degree of cognitive impairment correlated strongly with decreased function: CBCL, = -.17, = .01; VABS2, = -.28, < .001; repeated-grades, = .26, < .001. Presence of cognitive impairment was associated with increased risk of functional impairment: 3.47 (CIS); 1.71 (CBCL); 2.17 (VABS2); 2.97 (repeated-grades). Repeated-grades strongly associated with cognitive impairment and functional impairment. We found strong associations between HIV-infected youth functional impairment on CBCL, VABS2 and repeated-grades with degree of cognitive impairment; and that when cognitive impairment was present youth had higher risk of experiencing functional impairment as well. Asking whether youth have repeated a grade at school could be a helpful screening question for assessing potential functional impairment and provide clinicians with an indication as to whether a further in-depth assessment is required.
艾滋病毒相关的功能障碍可能导致病毒感染引起的认知障碍，因此，评估艾滋病毒感染者青少年中认知障碍与功能障碍之间的关系非常重要。我们旨在确定认知障碍是否与功能障碍相关，以及它是否具有更高的功能障碍风险。我们收集了父母对四个不同功能障碍评估量表上的青少年功能障碍的评分，并对青少年进行了认知测试，共纳入 203 名 HIV 感染者和 44 名未感染者。认知障碍的严重程度与功能下降密切相关：CBCL，r=-.17，p=0.01；VABS2，r=-.28，p<0.001；重复年级，r=-.26，p<0.001。认知障碍与功能障碍的风险增加有关：CIS，OR=3.47；CBCL，OR=1.71；VABS2，OR=2.17；重复年级，OR=2.97。重复年级与认知和功能障碍密切相关。我们发现，HIV 感染者青少年的 CBCL、VABS2 和重复年级的功能障碍与认知障碍的严重程度之间存在很强的相关性；当存在认知障碍时，青少年功能障碍的风险更高。询问青少年是否在学校留级可能是评估潜在功能障碍的有用筛查问题，并为临床医生提供是否需要进一步深入评估的指示。
