Division of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States of America.
Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States of America.
PLoS One. 2021 Feb 24;16(2):e0247414. doi: 10.1371/journal.pone.0247414. eCollection 2021.
Facemasks are recommended to reduce the spread of SARS-CoV-2, but concern about inadequate gas exchange is an often cited reason for non-compliance.
Among adult volunteers, do either cloth masks or surgical masks impair oxygenation or ventilation either at rest or during physical activity?
With IRB approval and informed consent, we measured heart rate (HR), transcutaneous carbon dioxide (CO2) tension and oxygen levels (SpO2) at the conclusion of six 10-minute phases: sitting quietly and walking briskly without a mask, sitting quietly and walking briskly while wearing a cloth mask, and sitting quietly and walking briskly while wearing a surgical mask. Brisk walking required at least a 10bpm increase in heart rate. Occurrences of hypoxemia (decrease in SpO2 of ≥3% from baseline to a value of ≤94%) and hypercarbia (increase in CO2 tension of ≥5 mmHg from baseline to a value of ≥46 mmHg) in individual subjects were collected. Wilcoxon signed-rank was used for pairwise comparisons among values for the whole cohort (e.g. walking without a mask versus walking with a cloth mask).
Among 50 adult volunteers (median age 33 years; 32% with a co-morbidity), there were no episodes of hypoxemia or hypercarbia (0%; 95% confidence interval 0-1.9%). In paired comparisons, there were no statistically significant differences in either CO2 or SpO2 between baseline measurements without a mask and those while wearing either kind of mask mask, both at rest and after walking briskly for ten minutes.
The risk of pathologic gas exchange impairment with cloth masks and surgical masks is near-zero in the general adult population.
口罩被推荐用于减少 SARS-CoV-2 的传播，但对气体交换不足的担忧是不遵守规定的一个常见原因。
在成年志愿者中，布制口罩或外科口罩是否会在休息或运动期间，无论是在静息状态还是在运动期间，都能影响氧合或通气？
在获得机构审查委员会批准和知情同意的情况下，我们在六个 10 分钟阶段结束时测量了心率（HR）、经皮二氧化碳（CO2）张力和氧水平（SpO2）：不戴口罩静坐和快速步行、戴布制口罩静坐和快速步行、戴外科口罩静坐和快速步行。快速步行需要至少使心率增加 10bpm。在个别受试者中收集了低氧血症（SpO2 从基线下降≥3%，至≤94%的值）和高碳酸血症（CO2 张力从基线增加≥5mmHg，至≥46mmHg 的值）的发生情况。Wilcoxon 符号秩检验用于比较整个队列中值的两两比较（例如，不戴口罩行走与戴布口罩行走）。
在 50 名成年志愿者（中位年龄 33 岁；32%有合并症）中，没有低氧血症或高碳酸血症（0%；95%置信区间 0-1.9%）的发生。在配对比较中，无论是在静息状态还是在快速行走十分钟后，无论是戴布制口罩还是外科口罩，与不戴口罩时的基线测量相比，CO2 或 SpO2 均无统计学差异。
在一般成年人群中，布制口罩和外科口罩导致病理气体交换受损的风险几乎为零。
