Hong Junshik, Ahn Seo-Yeon, Lee Yoo Jin, Lee Ji Hyun, Han Jung Woo, Kim Kyoung Ha, Yhim Ho-Young, Nam Seung-Hyun, Kim Hee-Jin, Song Jaewoo, Kim Sung-Hyun, Bang Soo-Mee, Kim Jin Seok, Mun Yeung-Chul, Bae Sung Hwa, Kim Hyun Kyung, Jang Seongsoo, Park Rojin, Choi Hyoung Soo, Kim Inho, Oh Doyeun
Division of Hematology-Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Department of Hematology-Oncology, Korea.
Chonnam National University Hwasun Hospital, Hwasun, Korea.
Blood Res. 2021 Mar 31;56(1):6-16. doi: 10.5045/br.2021.2020083.
Venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis, is a condition characterized by abnormal blood clot formation in the pulmonary arteries and the deep venous vasculature. It is often serious and sometimes even fatal if not promptly and appropriately treated. Moreover, the later consequences of VTE may result in reduced quality of life. The treatment of VTE depends on various factors, including the type, cause, and patient comorbidities. Furthermore, bleeding may occur as a side effect of VTE treatment. Thus, it is necessary to carefully weigh the benefits versus the risks of VTE treatment and to actively monitor patients undergoing treatment. Asian populations are known to have lower VTE incidences than Western populations, but recent studies have shown an increase in the incidence of VTE in Asia. A variety of treatment options are currently available owing to the introduction of direct oral anticoagulants. The current VTE treatment recommendation is based on evidence from previous studies, but it should be applied with careful consideration of the racial, genetic, and social characteristics in the Korean population.
静脉血栓栓塞症(VTE),包括肺栓塞和深静脉血栓形成,是一种以肺动脉和深静脉系统中异常血栓形成为特征的病症。如果不及时且适当地治疗,它通常很严重,有时甚至会致命。此外,VTE的后期后果可能导致生活质量下降。VTE的治疗取决于多种因素,包括类型、病因和患者的合并症。此外,出血可能作为VTE治疗的副作用而发生。因此,有必要仔细权衡VTE治疗的益处与风险,并积极监测正在接受治疗的患者。已知亚洲人群的VTE发病率低于西方人群,但最近的研究表明亚洲的VTE发病率有所上升。由于直接口服抗凝剂的引入,目前有多种治疗选择。当前的VTE治疗建议基于先前研究的证据,但在应用时应仔细考虑韩国人群的种族、遗传和社会特征。