米氮平对一名接受血液透析患者瘙痒和抑郁的起效时间差异

Miyahara Yu, Haruta-Tsukamoto Ayaka, Funahashi Hideki, Matsuo Hisae, Kanemaru-Kawazoe Anna, Nishimori Toshikazu, Ishida Yasushi

Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

SAGE Open Med Case Rep. 2021 Jan 23;9:2050313X20988408. doi: 10.1177/2050313X20988408. eCollection 2021.

A 63-year-old male receiving hemodialysis for renal insufficiency developed severe and widespread pruritus, which was unresponsive to antihistamines and severe depression with insomnia, agitation, and anxiety. The oral administration of 7.5 mg mirtazapine daily alleviated his severe pruritus after 4 days and severe depression after 14 days. Mirtazapine has potential as a therapeutic option for patients receiving hemodialysis with depressive disorder and severe pruritus unresponsive to antihistamines.

一名63岁因肾功能不全接受血液透析的男性出现了严重且广泛的瘙痒，抗组胺药对此无效，同时伴有严重抑郁、失眠、烦躁和焦虑。每天口服7.5毫克米氮平，4天后其严重瘙痒症状得到缓解，14天后严重抑郁症状也得到缓解。对于接受血液透析且患有抑郁症以及对抗组胺药无反应的严重瘙痒的患者，米氮平有作为一种治疗选择的潜力。