Division of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Population Science, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
J Assist Reprod Genet. 2021 May;38(5):1207-1213. doi: 10.1007/s10815-021-02115-2. Epub 2021 Feb 24.
To describe the association between contemporary total motile count (TMC), a measure of male factor infertility, and historic intergenerational family size.
This is a retrospective, population-based, cohort study of men who underwent semen analysis for infertility workup at University of Utah, with at least a single measure of TMC, who were linked to extensive genealogical data. Two thousand one hundred eighty-two pedigree branches of men with a measure of TMC within the UPDB were identified. We identified the average number of generations and offspring within each generation. Conditional logistic regression models were used to assess the association between the risk of having a TMC in the 5th or 25th percentile and intergenerational family size. Generalized estimating equations (GEE) were used to assess the association between interval-level TMC and the number of ancestral offspring.
We found no association between intergenerational size and TMC within the 5th percentile (TMC < 4 million; RR = 0.97, 95% CI 0.93-1.01) or the 25th percentile (TMC < 62 million; RR = 1.00, 95% CI 0.97-1.03). When TMC was analyzed as a continuous variable, we found that lower TMC is associated with smaller intergenerational family size. For every additional child in their ancestral pedigree, we observed an increase in TMC of 1.88 million (p = 0.03). Men in the top quartile for intergenerational family size had a TMC that was 48 million higher than men in the bottom quartile (p = 0.047).
We found an association between TMC and ancestral family size, suggesting that lower TMC is associated with smaller intergenerational family size.
描述当代总精子数（TMC）作为男性因素不育的衡量标准与历史世代家庭规模之间的关系。
这是一项在犹他大学进行的回顾性、基于人群的队列研究，研究对象为接受不育症检查的男性，他们至少有一次 TMC 测量值，并与广泛的系谱数据相关联。在 UPDB 中，确定了有 TMC 测量值的 2182 个男性系谱分支。我们确定了每一代的平均世代数和后代数。使用条件逻辑回归模型评估 TMC 处于第 5 百分位或第 25 百分位的风险与世代家庭规模之间的关联。使用广义估计方程（GEE）评估间隔水平 TMC 与祖先后代数量之间的关联。
我们发现，在第 5 百分位（TMC<400 万；RR=0.97，95%CI 0.93-1.01）或第 25 百分位（TMC<6200 万；RR=1.00，95%CI 0.97-1.03）时，世代大小与 TMC 之间没有关联。当 TMC 作为连续变量进行分析时，我们发现较低的 TMC 与较小的世代家庭规模相关。在他们的祖先系谱中每增加一个孩子，我们观察到 TMC 增加了 188 万（p=0.03）。在世代家庭规模最高的四分位数中，男性的 TMC 比在最低四分位数中的男性高 4800 万（p=0.047）。
我们发现 TMC 与祖先家庭规模之间存在关联，表明较低的 TMC 与较小的世代家庭规模相关。
