Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1185-1197. doi: 10.26355/eurrev_202102_24821.
Knee osteoarthritis (KOA) is currently indicated to be characterized by destruction of articular cartilage. The destruction can be described as an imbalance between synthesis and degradation of extracellular matrix (ECM) components. It is accompanied with changes of pro-inflammatory cytokines and degradation enzymes dominated by matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). Recent studies have revealed that microRNAs (miRNAs) are associated with synthesis and degradation of extracellular matrix (ECM). They play an important role in articular cartilage homeostasis of knee osteoarthritis (KOA). The related mechanisms include mediating the relevant enzymes and pro-inflammatory cytokines. The aim of this study is to reveal the potential microRNAs (miRNAs) and their corresponding upstream or downstream targeting on cartilage extracellular matrix (ECM) degradation in knee osteoarthritis (KOA).
7 databases were extensively searched with a theme of MicroRNAs (miRNAs) and knee osteoarthritis (KOA). The articles were searched regardless of publication status and language. The databases include PubMed, Cochrane Library, EMbase, China Biology Medicine (CBM), China National Knowledge Infrastructre (CNKI), WanFang Data and Chinese Scientific Journal Database (VIP).
This article reviews the microRNAs (miR-140, miR-146a, miR-25, miR-543, miR-19, miR-125b, miR-92a, miR-27b, miR-448, miR-558, miR-155) and their corresponding upstream or downstream in mediating cartilage extracellular matrix (ECM) degradation.
MicroRNAs (miRNAs) have been involved in the pathogenesis of KOA. They can directly regulate cartilage homeostasis by targeting on ECM degradation via corresponding upstream/downstream.
膝骨关节炎（KOA）目前被认为以关节软骨破坏为特征。这种破坏可以描述为细胞外基质（ECM）成分合成和降解之间的失衡。它伴随着以基质金属蛋白酶（MMP）和整合素金属蛋白酶与凝血酶 3 结构域（ADAMTS）为主的促炎细胞因子和降解酶的变化。最近的研究表明，microRNAs（miRNAs）与细胞外基质（ECM）的合成和降解有关。它们在膝骨关节炎（KOA）的关节软骨稳态中发挥重要作用。相关机制包括调节相关酶和促炎细胞因子。本研究旨在揭示膝骨关节炎（KOA）软骨细胞外基质（ECM）降解中潜在的 microRNAs（miRNAs）及其相应的上游或下游靶点。
以 microRNAs（miRNAs）和膝骨关节炎（KOA）为主题，广泛搜索了 7 个数据库。无论发表状态和语言如何，都对文章进行了搜索。数据库包括 PubMed、Cochrane Library、EMbase、中国生物医学文献数据库（CBM）、中国国家知识基础设施（CNKI）、万方数据和中国科学期刊数据库（VIP）。
本文综述了 microRNAs（miR-140、miR-146a、miR-25、miR-543、miR-19、miR-125b、miR-92a、miR-27b、miR-448、miR-558、miR-155）及其相应的上游或下游在介导软骨细胞外基质（ECM）降解中的作用。
microRNAs（miRNAs）已参与 KOA 的发病机制。它们可以通过相应的上下游直接调节 ECM 降解，从而直接调节软骨稳态。
