College of Basic Medicine, Second Military Medical University, Shanghai, China.
Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1399-1409. doi: 10.26355/eurrev_202102_24848.
Long noncoding RNAs (lncRNAs) are important participants in biological processes including cell proliferation, differentiation and death, as well as pathogenesis of various diseases. LncRNA differentiation antagonizing non-protein coding RNA (DANCR) is an emerging regulator in cell metabolism and many diseases besides cancers. DANCR is negative in epidermal, osteoblastic and endoderm differentiation, but positive in chondrogenic differentiation of progenitor cells. It is protective for calcification of the ligamentum flavum, stroke, acute myocardial infarction and arterial calcification, but a risk factor for bone loss, fracture healing and idiopathic pulmonary fibrosis. In addition, DANCR is a potential target for improving tissue regeneration. Mechanically, DANCR, a cytoplasmic lncRNA, sponges corresponding microRNAs or interacts with various proteins. This review aims to summarize the role of DANCR in progenitor cells and provide perspectives for further studies.
长链非编码 RNA（lncRNA）是细胞增殖、分化和死亡以及各种疾病发病机制等生物学过程中的重要参与者。lncRNA 分化拮抗非蛋白编码 RNA（DANCR）是细胞代谢和许多疾病（除癌症外）的新兴调节剂。DANCR 在表皮、成骨细胞和成内胚层分化中呈阴性，但在前体细胞的软骨分化中呈阳性。它对黄韧带钙化、中风、急性心肌梗死和动脉钙化有保护作用，但却是骨质流失、骨折愈合和特发性肺纤维化的危险因素。此外，DANCR 是改善组织再生的潜在靶点。从机制上讲，DANCR 作为一种细胞质 lncRNA，可以海绵吸附相应的 microRNA 或与各种蛋白质相互作用。本综述旨在总结 DANCR 在祖细胞中的作用，并为进一步的研究提供思路。
