miR-155（rs767649 A>T）和 miR-146a（rs57095329 A>G）多态性对埃及狼疮患者易感性的影响。
Impact of miR-155 (rs767649 A>T) and miR-146a (rs57095329 A>G) polymorphisms in System Lupus Erythematosus susceptibility in an Egyptian cohort.
机构信息
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
出版信息
Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1425-1435. doi: 10.26355/eurrev_202102_24850.
OBJECTIVE
Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disease. miR-155 and miR-146a were expressed in many autoimmune diseases such as rheumatoid arthritis. The aim of this study was to examine miR-155 rs767649 and miR-146a rs57095329 polymorphisms in SLE susceptibility in an Egyptian cohort and to investigate the correlation between them and clinical data and disease activity.
PATIENTS AND METHODS
The two SNPs were analyzed in 120 patients with SLE and 100 healthy controls using RT-PCR.
RESULTS
The TT genotype and T allele of miR-155 rs767649 were associated with a significant increase in the risk of SLE, particularly in females. On the other hand, miR-146a (rs57095329) polymorphism was not associated with SLE risk. The AT/TT genotypes of miR-155 rs767649 showed higher distributions among patients with higher SLEDAI and nephritis.
CONCLUSIONS
This study had demonstrated for the first time the association between miR-155 rs767649 and the risk of development of SLE in an Egyptian cohort, mostly in females.
目的
系统性红斑狼疮（SLE）是一种自身免疫性炎症性疾病。miR-155 和 miR-146a 在许多自身免疫性疾病中表达，如类风湿关节炎。本研究旨在探讨埃及人群中 miR-155 rs767649 和 miR-146a rs57095329 多态性与 SLE 易感性的关系，并研究它们与临床数据和疾病活动的相关性。
患者和方法
采用 RT-PCR 法分析 120 例 SLE 患者和 100 例健康对照者的两个 SNP。
结果
miR-155 rs767649 的 TT 基因型和 T 等位基因与 SLE 的发病风险显著增加相关，尤其是在女性中。另一方面，miR-146a(rs57095329)多态性与 SLE 风险无关。miR-155 rs767649 的 AT/TT 基因型在 SLEDAI 和肾炎患者中分布更高。
结论
本研究首次在埃及人群中证实了 miR-155 rs767649 与 SLE 发病风险的关联，尤其是在女性中。
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