Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Inflamm Res. 2022 Dec;71(12):1501-1517. doi: 10.1007/s00011-022-01643-6. Epub 2022 Oct 29.
MiR-155 is a member of the microRNAs (miRNAs) family and regulates gene expression post-transcriptionally by binding to the 3'UTR of target mRNA. MiR-155 has a critical role in both innate and adaptive immunity. MiR-155 is aberrantly expressed in inflammatory autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, Sjögren's syndrome, systemic sclerosis, and inflammatory bowel disease. Functional studies suggest that miR-155 is involved in development of these diseases. In vitro and in vivo experiments have shown that inhibition of miR-155 can alter disease progression or ameliorate disease symptoms.
A systematic review of relevant literatures published between January 1, 2005, and March 1, 2022 about miR-155 and its role in immune cells, autoimmune diseases was searched on PubMed, EMBASE, Google Scholar.
In this review, we comprehensively discussed the effects of miR-155, including role of miR-155 in different downstream signaling, which then differently regulate immune cells expression and functions. Furthermore, miR-155-mediated dysfunction of immune cells contributed to development of inflammatory autoimmune diseases. Therefore, miR-155 is expected to be a therapeutic target for inflammatory autoimmune diseases.
miR-155 是 microRNAs（miRNAs）家族的成员，通过与靶 mRNA 的 3'UTR 结合，在后转录水平上调节基因表达。miR-155 在先天和适应性免疫中都具有关键作用。miR-155 在炎症性自身免疫性疾病中异常表达，如类风湿关节炎、系统性红斑狼疮、多发性硬化症、1 型糖尿病、干燥综合征、系统性硬化症和炎症性肠病。功能研究表明，miR-155 参与了这些疾病的发展。体外和体内实验表明，抑制 miR-155 可以改变疾病进展或改善疾病症状。
我们在 PubMed、EMBASE 和 Google Scholar 上搜索了 2005 年 1 月 1 日至 2022 年 3 月 1 日期间发表的关于 miR-155 及其在免疫细胞和自身免疫性疾病中作用的相关文献的系统综述。
在这篇综述中，我们全面讨论了 miR-155 的作用，包括 miR-155 在不同下游信号通路中的作用，这些信号通路随后不同地调节免疫细胞的表达和功能。此外，miR-155 介导的免疫细胞功能障碍导致了炎症性自身免疫性疾病的发生。因此，miR-155 有望成为炎症性自身免疫性疾病的治疗靶点。
