Francès H
Département de Pharmacologie-INSERM U 302, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Pharmacol Biochem Behav. 1988 Mar;29(3):467-70. doi: 10.1016/0091-3057(88)90005-6.
A new model of social behavioral deficit and its reversal by drugs is described. Mice isolated for one week or more (isolated mice) behave differently from controls (grouped mice). When observed together under an inverted beaker, the isolated mice make significantly less escape attempts than the grouped mice. This behavioral deficit is a social one because it exists only when the isolated and grouped mice are tested together but not when they are tested singly. Several drugs impair this social behavioral deficit, particularly the 5-HT1B receptors agonists.
本文描述了一种新的社会行为缺陷模型及其药物逆转情况。隔离一周或更长时间的小鼠（隔离小鼠）与对照组（群居小鼠）行为不同。当在倒置烧杯下一起观察时，隔离小鼠的逃避尝试显著少于群居小鼠。这种行为缺陷是社会性的，因为它仅在隔离小鼠和群居小鼠一起测试时存在，而单独测试时不存在。几种药物可改善这种社会行为缺陷，尤其是5-HT1B受体激动剂。
