Frances H, Lienard C, Fermanian J, Lecrubier Y
Département de Pharmacologie, INSERM U 302, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Pharmacol Biochem Behav. 1989 Mar;32(3):637-42. doi: 10.1016/0091-3057(89)90010-5.
The behavior of mice isolated for 7-9 days (isolated mice) was compared to that of mice reared in groups (grouped mice). The method consisted of counting the number of escape attempts of the mice placed under an inverted beaker. When individually observed the isolated mice attempted to escape slightly but significantly more often than the grouped mice. When a pair of mice (one isolated + one grouped) were tested together, the number of escape attempts of the isolated mice was half of that of the grouped mice: this phenomenon was named the isolation-induced social behavioral deficit. These opposed behaviors may mean the same thing: an hyperreactivity to the novelty. In a variety of new situations under the beaker (presence of a lifeless object, of a grouped mouse or of an isolated mouse), the isolated mice were more reactive than the grouped mice. In conclusion, the social behavioral deficit test may be seen as a model of hyperreactivity with a behavioral inhibition.
将隔离7 - 9天的小鼠（隔离小鼠）的行为与成群饲养的小鼠（成群饲养小鼠）的行为进行比较。该方法包括计算置于倒置烧杯下的小鼠的逃脱尝试次数。单独观察时，隔离小鼠试图逃脱的次数比成群饲养小鼠略多，但明显更频繁。当一对小鼠（一只隔离小鼠 + 一只成群饲养小鼠）一起测试时，隔离小鼠的逃脱尝试次数是成群饲养小鼠的一半：这种现象被称为隔离诱导的社会行为缺陷。这些相反的行为可能意味着同一件事：对新奇事物的过度反应。在烧杯下的各种新情境中（有无生命物体、成群饲养小鼠或隔离小鼠存在），隔离小鼠比成群饲养小鼠反应更强烈。总之，社会行为缺陷测试可被视为一种具有行为抑制的过度反应模型。
