Lenègre A, Chermat R, Avril I, Stéru L, Porsolt R D
I.T.E.M.-Labo, Kremlin-Bicêtre, France.
Pharmacol Biochem Behav. 1988 Mar;29(3):625-9. doi: 10.1016/0091-3057(88)90030-5.
The effects of piracetam on the amnesias induced by scopolamine, diazepam and electroconvulsive shock (ECS) were studied in a passive avoidance procedure in the mouse and compared with the interactions of piracetam with the major behavioral effects of these treatments, namely scopolamine-induced hyperactivity, diazepam-induced release of punished behavior (Four Plates Test) and ECS-induced convulsions. Amnesia was induced by injecting scopolamine or diazepam (1 mg/kg, IP) 30 minutes before or applying ECS immediately after the first session (S1) of the passive avoidance task. Piracetam was studied at 3 doses (512, 1024 and 2048 mg/kg) administered PO 60 minutes before S1. Retention was measured 24 hours later (S2) in the absence of any treatment. Piracetam dose-dependently attenuated the memory deficits induced by the three amnesic treatments but did not affect either scopolamine-induced hyperactivity, diazepam-induced release of punished behavior or ECS-induced convulsions. These results point to the specificity of piracetam's anti-amnesic activity and, in particular, suggest that piracetam can suppress the memory disturbances induced by diazepam without affecting diazepam's anxiolytic activity. The test battery employed would therefore seem highly suitable for evaluating the potential nootropic activity of novel compounds.
在小鼠的被动回避实验中，研究了吡拉西坦对东莨菪碱、地西泮和电惊厥休克（ECS）诱导的失忆症的影响，并将其与吡拉西坦对这些处理的主要行为效应的相互作用进行了比较，这些主要行为效应即东莨菪碱诱导的多动、地西泮诱导的受罚行为释放（四板试验）和ECS诱导的惊厥。在被动回避任务的第一次训练（S1）前30分钟注射东莨菪碱或地西泮（1mg/kg，腹腔注射）或在S1后立即施加ECS来诱导失忆症。在S1前60分钟口服给予3种剂量（512、1024和2048mg/kg）的吡拉西坦进行研究。24小时后（S2）在未进行任何处理的情况下测量记忆保持情况。吡拉西坦剂量依赖性地减轻了三种失忆处理诱导的记忆缺陷，但不影响东莨菪碱诱导的多动、地西泮诱导的受罚行为释放或ECS诱导的惊厥。这些结果表明了吡拉西坦抗失忆活性的特异性，特别是表明吡拉西坦可以抑制地西泮诱导的记忆障碍而不影响地西泮的抗焦虑活性。因此，所采用的测试组合似乎非常适合评估新型化合物的潜在益智活性。
