Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm.
Section for Rheumatology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund.
Rheumatology (Oxford). 2021 Jul 1;60(7):3121-3133. doi: 10.1093/rheumatology/keab190.
We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature.
This study followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement of 2009. We conducted a systematic search in MEDLINE, Web of Science and Embase to identify articles reporting incidence and/or prevalence of SSc. Two authors conducted the search, reviewed articles for inclusion and extracted relevant data. We used random-effects models to estimate the pooled prevalence and incidence of SSc and performed subgroup analyses by sex, case definition and region to investigate heterogeneity. We explored the association between calendar period and reported estimates using meta-regression.
Among 6983 unique records identified, we included 61 studies of prevalence and 39 studies of incidence in the systematic review. The overall pooled prevalence of SSc was 17.6 (95% CI 15.1, 20.5) per 100 000 and the overall pooled incidence rate of SSc was 1.4 (95% CI 1.1, 1.9) per 100 000 person-years. We observed significant regional variations in reported estimates; studies conducted in North America reported considerably higher estimates than other regions. The pooled incidence and prevalence in women were five times higher than in men. More recent studies reported higher estimates than older ones.
In this comprehensive review of the incidence and prevalence of SSc across the world, there was large heterogeneity among estimates, which should be taken into consideration when interpreting the results.
本研究旨在对涵盖所有文献的 SSc 发病率和患病率进行系统评价和荟萃分析。
本研究遵循 2009 年《系统评价和荟萃分析的首选报告项目》（PRISMA）声明的建议。我们在 MEDLINE、Web of Science 和 Embase 中进行了系统搜索，以确定报告 SSc 发病率和/或患病率的文章。两名作者进行了搜索、评估纳入文章并提取了相关数据。我们使用随机效应模型估计 SSc 的汇总患病率和发病率，并按性别、病例定义和地区进行亚组分析以探究异质性。我们使用荟萃回归探讨了日历时间与报告估计值之间的关系。
在 6983 条独特记录中，我们纳入了系统评价中的 61 项患病率研究和 39 项发病率研究。SSc 的总体汇总患病率为每 10 万人 17.6（95%CI 15.1，20.5），SSc 的总体汇总发病率为每 10 万人年 1.4（95%CI 1.1，1.9）。我们观察到报告估计值存在显著的地域差异；在北美的研究报告的估计值明显高于其他地区。女性的汇总发病率和患病率是男性的五倍。较新的研究报告的估计值高于较旧的研究。
在对全球 SSc 的发病率和患病率进行的这项全面综述中，估计值存在很大的异质性，在解释结果时应考虑到这一点。
