Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222, Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea, 04763, South Korea.
Department of Statistics, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu, Republic of Korea, 41566, South Korea.
Semin Arthritis Rheum. 2020 Jun;50(3):526-533. doi: 10.1016/j.semarthrit.2019.11.007. Epub 2019 Nov 15.
To estimate the prevalence, medical utilization, and recent changes in the economic burden of autoimmune rheumatic diseases (AIRDs) in Korea.
Using a nationwide claims database that includes all medical claims made by approximately 50 million Korean residents, the prevalences of seropositive rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), and others between 2012 and 2016 were calculated. Changes in medical utilization and the direct medical costs of each AIRD from 2012 to 2016 were also evaluated.
Based on the data for 2016, seropositive RA was the most common AIRD in Korea with 96,330 cases (188.5/100,000 population), followed by AS (30,006, 58.7/100,000 population), SLE (19,441, 38.0/100,000 population), Behçet's disease (BD, 14,943, 29.2/100,000 population), primary Sjögren syndrome (pSS, 12,018, 23.5/100,000 population), and systemic sclerosis (SSc, 3606, 7.1/100,000 population). In terms of medical utilization, patients with eosinophilic granulomatosis with polyangiitis visited outpatient clinics the most frequently (9.8 times/year/patient), while hospitalization was most frequent in microscopic polyangiitis patients (1.0 time/year/patient). Total medical costs for all AIRDs increased from $154,348,011 in 2012 to $262,481,974 in 2016. The annual medical cost per patient in 2016 was the highest in microscopic polyangiitis ($6223/year), followed by psoriatic arthritis ($3,362/year), and granulomatosis with polyangiitis ($2823/year).
In Korea, the most prevalent AIRD is seropositive RA, followed by AS, SLE, BD, pSS, and SSc. The economic burden of AIRDs has risen substantially in the last 5 years due not only to an increase in their prevalence but also to an increase in medical costs per patient.
评估韩国自身免疫性风湿病（AIRD）的患病率、医疗利用情况和近期经济负担的变化。
利用包含约 5000 万韩国居民所有医疗索赔的全国性索赔数据库，计算了 2012 年至 2016 年期间血清阳性类风湿关节炎（RA）、强直性脊柱炎（AS）、系统性红斑狼疮（SLE）和其他疾病的患病率。还评估了 2012 年至 2016 年期间每种 AIRD 的医疗利用和直接医疗费用的变化。
根据 2016 年的数据，血清阳性 RA 是韩国最常见的 AIRD，有 96330 例（188.5/100000 人口），其次是 AS（30006，58.7/100000 人口）、SLE（19441，38.0/100000 人口）、贝赫切特病（BD，14943，29.2/100000 人口）、原发性干燥综合征（pSS，12018，23.5/100000 人口）和系统性硬化症（SSc，3606，7.1/100000 人口）。就医疗利用而言，嗜酸性粒细胞性肉芽肿伴多血管炎患者就诊次数最多（9.8 次/年/患者），而显微镜下多血管炎患者住院次数最多（1.0 次/年/患者）。所有 AIRD 的总医疗费用从 2012 年的 15434.8011 亿美元增加到 2016 年的 26248.1974 亿美元。2016 年每位患者的年医疗费用在显微镜下多血管炎患者中最高（6223 美元/年），其次是银屑病关节炎（3362 美元/年）和肉芽肿伴多血管炎（2823 美元/年）。
在韩国，最常见的 AIRD 是血清阳性 RA，其次是 AS、SLE、BD、pSS 和 SSc。由于疾病患病率的增加以及每位患者的医疗费用的增加，过去 5 年来 AIRD 的经济负担大幅增加。
