University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9068, USA.
Curr Pain Headache Rep. 2021 Feb 25;25(3):17. doi: 10.1007/s11916-020-00930-3.
While ketamine is an established anesthetic, its role in the management of acute surgical pain is less certain. Therefore, a literature review is warranted to examine the role of ketamine in acute pain management.
The use of ketamine appears to be most efficacious in larger procedures that lead to increased systemic inflammation or extensive tissue damage. In addition, ketamine seems to be most successful when administered consistently throughout a procedure, such as by an infusion instead of a single bolus, in order to have adequate dosing for an analgesic effect. Therefore, the focus of research should be on procedures that lead to moderate to severe pain using frequent dosing to determine the most effective role of ketamine. Most importantly, the current literature shows that ketamine can be used as a successful part of multimodal anesthesia with few side effects in patients undergoing major procedures associated with moderate to severe pain.
虽然氯胺酮是一种已被确立的麻醉剂，但它在急性手术疼痛管理中的作用尚不确定。因此，有必要进行文献综述，以检查氯胺酮在急性疼痛管理中的作用。
氯胺酮的使用似乎在导致全身炎症或广泛组织损伤的较大手术中最有效。此外，当在整个手术过程中持续给予氯胺酮时，例如通过输注而不是单次推注，以获得足够的镇痛效果时，氯胺酮似乎最成功。因此，研究的重点应该放在使用频繁剂量导致中度至重度疼痛的手术上，以确定氯胺酮最有效的作用。最重要的是，目前的文献表明，氯胺酮可以作为多模式麻醉的成功组成部分，在接受与中度至重度疼痛相关的大手术的患者中使用，副作用很少。
