钌催化膦的P导向远程ε-C-H烷基化反应
Ruthenium-Catalyzed P-Directed Remote ε-C-H Alkylation of Phosphines.
作者信息
Xu Hui-Bei, Chen Yin-Jun, Chai Xin-Yue, Yang Jia-Hui, Xu Yan-Jun, Dong Lin
机构信息
College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Org Lett. 2021 Mar 19;23(6):2052-2056. doi: 10.1021/acs.orglett.0c03906. Epub 2021 Feb 25.
The ruthenium-catalyzed remote ε-C-H alkylation of phosphines with tertiary alkyl halides has been developed. This novel P-directed C-H activation strategy tolerated various functional groups and delivered a wide variety of modified phosphines with excellent site selectivity. Preliminary mechanistic studies indicated that a P-assisted cyclometalation/remote σ-activation pathway might be involved in this methodology.
已开发出钌催化的叔烷基卤化物与膦的远程ε-C-H烷基化反应。这种新颖的磷导向C-H活化策略可耐受各种官能团，并能以优异的位点选择性提供多种改性膦。初步机理研究表明，该方法可能涉及磷辅助的环金属化/远程σ-活化途径。
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