Chen Yuxia, Zhan Xue, Wang Donghai
Department of Gastroenterology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.
Department of Respiratory Disease, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.
J Asthma. 2022 May;59(5):890-900. doi: 10.1080/02770903.2021.1892752. Epub 2021 Mar 8.
The association between () and childhood asthma is unclear. Thus, the aim of this study was to explore the association between and childhood asthma. A literature search, study selection, and data extraction were performed independently and in duplicate. Data were analyzed using STATA software. Eighteen studies enrolling 17,196 children were analyzed. All studies were of moderate-to-high quality. Four studies subcategorized infection according to CagA status. Overall, there was a significant negative association between and risk for childhood asthma (OR = 0.68; 95% CI, 0.54-0.87; = 0.002), with no/marginal publication bias identified by the Egger's test and the Begg's test ( = 0.162 and = 0.198, respectively). The observed inverse association persisted for CagA(+) strains of (OR = 0.58; 95% CI, 0.35-0.96; = 0.034) but not for CagA(-) strains (OR = 0.52; 95% CI, 0.12-2.28; = 0.387). There was no significant difference between studies with respect to study design, participant age, geographical region, and method of measuring . The evidence suggests that infection, particularly CagA(+) infection, is inversely associated with the risk of childhood asthma. Supplemental data for this article can be accessed at publisher's website.
（）与儿童哮喘之间的关联尚不清楚。因此，本研究的目的是探讨（）与儿童哮喘之间的关联。独立且重复地进行了文献检索、研究筛选和数据提取。使用STATA软件进行数据分析。对纳入17196名儿童的18项研究进行了分析。所有研究质量为中到高。四项研究根据CagA状态对（）感染进行了亚分类。总体而言，（）与儿童哮喘风险之间存在显著负相关（OR = 0.68；95%CI，0.54 - 0.87；P = 0.002），Egger检验和Begg检验未发现/存在边缘性发表偏倚（分别为P = 0.162和P = 0.198）。观察到的负相关在（）的CagA（+）菌株中持续存在（OR = 0.58；95%CI，0.35 - 0.96；P = 0.034），但在CagA（-）菌株中不存在（OR = 0.52；95%CI，0.12 - 2.28；P = 0.387）。在研究设计、参与者年龄、地理区域和测量（）的方法方面，各研究之间没有显著差异。证据表明，（）感染，特别是CagA（+）（）感染，与儿童哮喘风险呈负相关。本文的补充数据可在出版商网站获取。
