一种具有三合一多功能的 2-吡啶酮修饰的锌酞菁，用于光动力疗法。
A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy.
机构信息
College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, Jiangsu 210023, China.
出版信息
Chem Commun (Camb). 2021 Mar 28;57(25):3127-3130. doi: 10.1039/d1cc00645b. Epub 2021 Feb 25.
A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (O) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.
一种 2-吡啶酮修饰的锌酞菁（记为 ZnPc-PYR）在癌症的光动力疗法（PDT）治疗中实现了一石三鸟的效果。ZnPc-PYR 可以同时被 665nm 和 808nm 光激发，以治疗浅层和深层肿瘤，储存并缓慢释放单线态氧（O）以提高其利用率，并下调 HIF-1（缺氧诱导因子 1）表达水平，以增强肿瘤细胞在缺氧条件下对 PDT 治疗的敏感性。
Zotero 插件