纳米级金属有机层分离酞菁用于高效线粒体靶向光动力治疗。
Nanoscale Metal-Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy.
出版信息
J Am Chem Soc. 2021 Feb 10;143(5):2194-2199. doi: 10.1021/jacs.0c12330. Epub 2021 Feb 2.
Abstract
Zinc-phthalocyanine (ZnPc) photosensitizers (PSs) have shown great potential in photodynamic therapy (PDT) owing to their strong absorption at long wavelengths (650-750 nm), high triplet quantum yields, and biocompatibility. However, the clinical utility of ZnPc PSs is limited by their poor solubility and tendency to aggregate in aqueous environments. Here we report the design of a new nanoscale metal-organic layer (nMOL) assembly, ZnOPPc@nMOL, with ZnOPPc [ZnOPPc = zinc(II)-2,3,9,10,16,17,23,24-octa(4-carboxyphenyl)phthalocyanine] PSs supported on the secondary building units (SBUs) of a Hf nMOL for PDT. Upon irradiation, SBU-bound ZnOPPc PSs absorb 700 nm light and efficiently sensitize the formation of singlet oxygen by preventing aggregation-induced self-quenching of ZnOPPc excited states. With intrinsic mitochondria-targeting capability, ZnOPPc@nMOL showed exceptional PDT efficacy with >99% tumor growth inhibition and 40-60% cure rates on two mouse models of colon cancer.
摘要
锌酞菁（ZnPc）光敏剂（PSs）因其在长波长（650-750nm）处的强吸收、高三重态量子产率和生物相容性，在光动力疗法（PDT）中显示出巨大的潜力。然而，ZnPc PSs 的临床应用受到其在水相环境中较差的溶解度和聚集倾向的限制。在此，我们报告了一种新型纳米级金属有机层（nMOL）组装体 ZnOPPc@nMOL 的设计，其中 ZnOPPc [ZnOPPc=锌（II）-2,3,9,10,16,17,23,24-八（4-羧基苯基）酞菁] PSs 负载在 Hf nMOL 的次级构筑单元（SBU）上，用于 PDT。在照射下，SBU 结合的 ZnOPPc PSs 吸收 700nm 光，并通过防止 ZnOPPc 激发态的聚集诱导自猝灭，有效地敏化单线态氧的形成。由于具有内在的线粒体靶向能力，ZnOPPc@nMOL 在两种结肠癌小鼠模型中表现出优异的 PDT 疗效，肿瘤生长抑制率超过 99%，治愈率为 40-60%。
相似文献
1
Nanoscale Metal-Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy.纳米级金属有机层分离酞菁用于高效线粒体靶向光动力治疗。
J Am Chem Soc. 2021 Feb 10;143(5):2194-2199. doi: 10.1021/jacs.0c12330. Epub 2021 Feb 2.
2
Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy.具有酞菁交错堆叠结构的纳米级共价有机框架用于线粒体靶向光动力治疗
J Am Chem Soc. 2024 Jan 10;146(1):849-857. doi: 10.1021/jacs.3c11092. Epub 2023 Dec 22.
3
Nanoscale Metal-Organic Framework Confines Zinc-Phthalocyanine Photosensitizers for Enhanced Photodynamic Therapy.纳米级金属有机框架封装锌酞菁光敏剂用于增强光动力疗法
J Am Chem Soc. 2021 Sep 1;143(34):13519-13524. doi: 10.1021/jacs.1c07379. Epub 2021 Aug 23.
4
Monomer zinc phthalocyanine/upconversion nanoparticle coated with hyaluronic acid crosslinked gel as NIR light-activated drug for in vitro photodynamic therapy.以透明质酸交联凝胶包覆的单体锌酞菁/上转换纳米颗粒作为用于体外光动力疗法的近红外光激活药物。
Dalton Trans. 2016 Sep 27;45(38):15170-15179. doi: 10.1039/c6dt01929c.
5
Enhancing antitumor efficacy of NIR-I region zinc phthalocyanine@upconversion nanoparticle through lysosomal escape and mitochondria targeting.通过溶酶体逃逸和靶向线粒体来增强近红外一区锌酞菁@上转换纳米粒子的抗肿瘤疗效。
J Photochem Photobiol B. 2024 Jun;255:112923. doi: 10.1016/j.jphotobiol.2024.112923. Epub 2024 Apr 24.
6
Facile development of biodegradable polymer-based nanotheranostics: Hydrophobic photosensitizers delivery, fluorescence imaging and photodynamic therapy.基于生物可降解聚合物的纳米诊疗一体化的简易制备：疏水性光敏剂的递药、荧光成像和光动力治疗。
J Photochem Photobiol B. 2019 Apr;193:39-50. doi: 10.1016/j.jphotobiol.2019.02.007. Epub 2019 Feb 21.
7
Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.水溶性非聚集锌酞菁及其用于光动力疗法的体外研究。
Chem Commun (Camb). 2013 Dec 11;49(95):11149-51. doi: 10.1039/c3cc44609c.
8
Zinc octa-n-alkyl phthalocyanines in photodynamic therapy: photophysical properties, accumulation and apoptosis in cell cultures, studies in erythrocytes and topical application to Balb/c mice skin.光动力疗法中的八正烷基酞菁锌：光物理性质、细胞培养中的积累与凋亡、红细胞研究以及在Balb/c小鼠皮肤上的局部应用
Photochem Photobiol Sci. 2003 Jun;2(6):660-7. doi: 10.1039/b211348a.
9
Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy.α-(8-喹啉氧基)酞菁锌介导的光动力疗法治疗银屑病的效果及机制
Cell Physiol Biochem. 2017;44(1):200-214. doi: 10.1159/000484647. Epub 2017 Nov 9.
10
Octa-alkyl zinc phthalocyanines: potential photosensitizers for use in the photodynamic therapy of cancer.八烷基锌酞菁：用于癌症光动力治疗的潜在光敏剂。
Photochem Photobiol. 1995 Sep;62(3):542-5. doi: 10.1111/j.1751-1097.1995.tb02381.x.
引用本文的文献
1
Light-triggered toll-like receptor activation in a nanoscale metal-organic framework for synergistic PDT and cancer immunotherapy.用于协同光动力疗法和癌症免疫疗法的纳米级金属有机框架中的光触发Toll样受体激活
Chem Sci. 2025 Aug 6. doi: 10.1039/d5sc03446a.
2
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions.用光动力疗法和纳米技术对抗癌症：当前挑战与未来方向
Int J Mol Sci. 2025 Mar 25;26(7):2969. doi: 10.3390/ijms26072969.
3
A Hypoxia-Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High-Specificity Cancer Phototherapy.一种用于可切换体内光声成像和高特异性癌症光疗的亲水性I型光敏剂的缺氧触发生物还原。
Angew Chem Int Ed Engl. 2025 Jun 17;64(25):e202506412. doi: 10.1002/anie.202506412. Epub 2025 Apr 17.
4
Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy.工程化缺氧响应性白蛋白纳米颗粒介导线粒体自噬调控用于癌症治疗。
Nat Commun. 2025 Jan 11;16(1):596. doi: 10.1038/s41467-025-55905-y.
5
Phage Display Against 2D Metal-Organic Nanosheets as a New Route to Highly Selective Biomolecular Recognition Surfaces.针对二维金属有机纳米片的噬菌体展示：通往高选择性生物分子识别表面的新途径
Small. 2025 Jul;21(29):e2406339. doi: 10.1002/smll.202406339. Epub 2024 Nov 13.
6
Optically accessible long-lived electronic biexcitons at room temperature in strongly coupled H- aggregates.在强耦合H聚集体中室温下可光学探测的长寿命电子双激子。
Nat Commun. 2024 Sep 27;15(1):8280. doi: 10.1038/s41467-024-52341-2.
7
Facile synthesis of a hydrazone-based zinc(ii) complex for ferroptosis-augmented sonodynamic therapy.用于铁死亡增强型声动力治疗的腙基锌（II）配合物的简便合成
Chem Sci. 2024 May 17;15(26):10027-10035. doi: 10.1039/d4sc02102a. eCollection 2024 Jul 3.
8
In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar-Zinc Phthalocyanine Conjugates.受保护和未受保护的糖-锌酞菁共轭物的体外和体内抗银屑病疗效
Pharmaceutics. 2024 Jun 20;16(6):838. doi: 10.3390/pharmaceutics16060838.
9
Enabling a bioinspired ,,-copper coordination motif through spatial control in UiO-67: synthesis and reactivity.通过对UiO-67进行空间控制实现仿生的铜配位结构：合成与反应活性
Dalton Trans. 2024 May 14;53(19):8141-8153. doi: 10.1039/d3dt03096b.
10
Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies.光动力疗法诱导的抗肿瘤免疫：影响因素与协同增强策略
Pharmaceutics. 2023 Nov 11;15(11):2617. doi: 10.3390/pharmaceutics15112617.
本文引用的文献
1
Metal-Organic Layers for Synergistic Lewis Acid and Photoredox Catalysis.金属有机层用于协同路易斯酸和光氧化还原催化。
J Am Chem Soc. 2020 Jan 29;142(4):1746-1751. doi: 10.1021/jacs.9b12593. Epub 2020 Jan 15.
2
Biomimetic Platinum Nanozyme Immobilized on 2D Metal-Organic Frameworks for Mitochondrion-Targeting and Oxygen Self-Supply Photodynamic Therapy.仿生铂纳米酶固定在二维金属有机骨架上用于线粒体靶向和氧气自供应的光动力治疗。
ACS Appl Mater Interfaces. 2020 Jan 15;12(2):1963-1972. doi: 10.1021/acsami.9b14958. Epub 2020 Jan 2.
3
The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer.酞菁作为先进的光动力治疗癌症光敏剂的独特特征和前景。
Chem Soc Rev. 2020 Feb 21;49(4):1041-1056. doi: 10.1039/c9cs00129h. Epub 2019 Dec 17.
4
Nd -Sensitized Upconversion Metal-Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy.基于上转换的钕敏化金属有机框架用于线粒体靶向的放大光动力治疗。
Angew Chem Int Ed Engl. 2020 Feb 10;59(7):2634-2638. doi: 10.1002/anie.201911508. Epub 2020 Jan 9.
5
Multifunctional Nanoscale Metal-Organic Layers for Ratiometric pH and Oxygen Sensing.多功能纳米级金属有机层用于比率 pH 和氧传感。
J Am Chem Soc. 2019 Dec 4;141(48):18964-18969. doi: 10.1021/jacs.9b11024. Epub 2019 Nov 22.
6
Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy.低剂量 X 射线放射动力疗法通过纳米级金属有机框架增强检查点封锁免疫疗法。
Nat Biomed Eng. 2018 Aug;2(8):600-610. doi: 10.1038/s41551-018-0203-4. Epub 2018 Mar 26.
7
Nanoscale Metal-Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-Enhancement.纳米级金属有机骨架的层次结构将高 Z 组件结合在一起，用于多种放射性增强。
J Am Chem Soc. 2019 May 1;141(17):6859-6863. doi: 10.1021/jacs.9b03029. Epub 2019 Apr 22.
8
Titanium-Based Nanoscale Metal-Organic Framework for Type I Photodynamic Therapy.基于钛的纳米级金属有机骨架用于 I 型光动力疗法。
J Am Chem Soc. 2019 Mar 13;141(10):4204-4208. doi: 10.1021/jacs.8b13804. Epub 2019 Feb 26.
9
Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer.用于癌症光疗的纳米级金属有机框架
Coord Chem Rev. 2019 Jan 15;379:65-81. doi: 10.1016/j.ccr.2017.09.007. Epub 2017 Oct 21.
10
Nanoscale Metal-Organic Layers for Radiotherapy-Radiodynamic Therapy.用于放射治疗-放射动力疗法的纳米级金属有机层
J Am Chem Soc. 2018 Dec 12;140(49):16971-16975. doi: 10.1021/jacs.8b11593. Epub 2018 Nov 28.
Zotero 插件