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长期辐射暴露期间恶喹酸的辐射防护特性

[Radioprotective properties of oxolinic acid during long-term exposure to radiation].

作者信息

Pukhov V V, Daniiarov S B

出版信息

Radiobiologiia. 1988 Mar-Apr;28(2):279-81.

PMID:3363111
Abstract

The antioxidant activity of oxolinic acid was studied in mongrel mice during the prolonged (6-8 hours) exposure to ionizing radiation. The drug administered before irradiation was shown to increase (by 7 to 33 per cent) the survival rate of mice. The effect was maximum after the subcutaneous injection. The results obtained on the effect of oxolinic acid on DNA synthesis by bone marrow karyocytes are submitted.

摘要

在杂种小鼠长时间(6 - 8小时)暴露于电离辐射期间,对恶喹酸的抗氧化活性进行了研究。结果表明,在照射前给药该药物可提高小鼠的存活率(提高7%至33%)。皮下注射后效果最佳。本文提交了关于恶喹酸对骨髓有核细胞DNA合成影响的研究结果。

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