Miller D L, Chang R, Wells W T, Dowjat B A, Malinosky R M, Doppman J L
Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Radiology. 1988 Jun;167(3):607-11. doi: 10.1148/radiology.167.3.3363118.
Effect of contrast material dose on clinically evident change in renal function was studied prospectively in 200 examinations requiring intravenous or intraarterial administration of contrast material. All patients were adequately hydrated. Blood urea nitrogen and serum creatinine were measured before and after the procedure. Ionic and nonionic contrast agents were used. Total dose of contrast material ranged from 30 to 530 mL (mean, 237 mL). There was no tendency to give smaller doses to patients with preexisting renal impairment and no relationship between total dose and patient age. No consistent clinical effect on renal function was demonstrated with increasing dose, regardless of whether ionic or nonionic agents were used. In adequately hydrated low-risk patients with predominantly normal initial renal function and within the dose range studied, there does not appear to be any consistent clinical change in renal function with increasing contrast material dose.
在200例需要静脉或动脉注射造影剂的检查中，前瞻性地研究了造影剂剂量对肾功能临床明显变化的影响。所有患者均充分水化。在检查前后测量血尿素氮和血清肌酐。使用了离子型和非离子型造影剂。造影剂的总剂量为30至530毫升（平均237毫升）。对于已有肾功能损害的患者，没有给予较小剂量的倾向，且总剂量与患者年龄之间没有关系。无论使用离子型还是非离子型造影剂，随着剂量增加，均未显示出对肾功能有一致的临床影响。在初始肾功能主要正常且充分水化的低风险患者中，在所研究的剂量范围内，随着造影剂剂量增加，肾功能似乎没有任何一致的临床变化。
