Pathria M N, Bjorkengren A G, Jacob J, Kaplan P A, Kursunoglu S, Pate D, Sartoris D J, Resnick D
Department of Radiology, University of California San Diego Medical Center.
Radiology. 1988 Jun;167(3):793-5. doi: 10.1148/radiology.167.3.3363142.
To test the hypothesis that there are significant differences in the radiographic appearance of rheumatoid arthritis between men and women, the authors blindly evaluated bilateral hand and wrist radiographs in 32 men with definite rheumatoid arthritis and 32 age- and disease duration-matched women (mean age, 56.4 years; mean disease duration, 10.5 years). Radiographically, disease distribution and severity were identical in these matched groups. Superimposed osteoarthritis was frequent in both groups and related to age. Ill-defined bone proliferation was present in 13 of 64 hands in both groups. Cystic changes and well-defined erosions were present in 12 of 64 male hands and six of 64 female hands, but this difference was not statistically significant. In women, presence of cysts and bone proliferation was related to disease duration, whereas men exhibited these atypical features independent of disease duration. There was no statistically significant difference in the frequencies of typical and atypical features of rheumatoid arthritis between the two sexes, and the authors postulate that previously reported differences relate to patient selection and lack of adequate matching.
为验证男性和女性类风湿关节炎的影像学表现存在显著差异这一假设，作者对32例确诊为类风湿关节炎的男性患者以及32例年龄和病程相匹配的女性患者（平均年龄56.4岁；平均病程10.5年）的双手及腕部X线片进行了盲法评估。在影像学上，这些匹配组中的疾病分布和严重程度相同。两组中重叠性骨关节炎均很常见且与年龄相关。两组64只手中有13只出现了边界不清的骨质增生。64只男性手中有12只出现囊性改变和边界清晰的侵蚀，64只女性手中有6只出现，但这种差异无统计学意义。在女性中，囊肿和骨质增生的出现与病程有关，而男性出现这些非典型特征与病程无关。两性之间类风湿关节炎典型和非典型特征的频率无统计学显著差异，作者推测先前报道的差异与患者选择及缺乏充分匹配有关。
