红细胞生理和病理生理学的生物物理和流变学标志物。
Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology.
机构信息
Mechanical and Aerospace Engineering Department, Case Western Reserve University.
Biomedical Engineering Department, Case Western Reserve University.
出版信息
Curr Opin Hematol. 2021 May 1;28(3):138-149. doi: 10.1097/MOH.0000000000000639.
PURPOSE OF REVIEW
This review summarizes the significant biophysical and rheological aspects of red blood cell physiology and pathophysiology in relation to recent advances in microfluidic biomarker assays and emerging targeted or curative intent therapies.
RECENT FINDINGS
Alterations in red cell biophysical properties and blood rheology have been associated with numerous hematologic and circulatory disorders. Recent advances in biomarker assays enable effective assessment of these biophysical and rheological properties in normoxia or physiological hypoxia in a clinically meaningful way. There are emerging targeted or curative therapies that aim to improve red cell pathophysiology, especially in the context of inherited hemoglobin disorders, such as sickle cell disease.
SUMMARY
Red cell pathophysiology can be therapeutically targeted and the improvements in membrane and cellular biophysics and blood rheology can now be feasibly assessed via new microfluidic biomarker assays. Recent advances provide a new hope and novel treatment options for major red cell ailments, including inherited hemoglobin disorders, membrane disorders, and other pathologies of the red cell, such as malaria.
目的综述
本文总结了红细胞生理和病理生理学中重要的生物物理和流变学方面，涉及最近在微流控生物标志物检测方面的进展和新兴的靶向或根治性治疗方法。
最近的发现
红细胞生物物理特性和血液流变学的改变与许多血液学和循环系统疾病有关。生物标志物检测方面的最新进展能够以有临床意义的方式有效地评估这些生物物理和流变学特性在常氧或生理缺氧下的情况。目前有一些新兴的靶向或根治性治疗方法旨在改善红细胞病理生理学，特别是在遗传性血红蛋白疾病（如镰状细胞病）的背景下。
总结
可以针对红细胞病理生理学进行治疗，并且现在可以通过新的微流控生物标志物检测来评估膜和细胞生物物理学以及血液流变学的改善。最近的进展为主要的红细胞疾病，包括遗传性血红蛋白疾病、膜疾病以及疟疾等红细胞的其他病理学提供了新的希望和新的治疗选择。
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