Jin Xu, Zhang Yingnan, Wang Ding, Zhang Xiaoru, Li Yue, Wang Di, Liang Yipeng, Wang Jingwei, Zheng Lingyue, Song Haoze, Zhu Xu, Liang Jing, Ma Jinfa, Gao Jie, Tong Jingyuan, Shi Lihong
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Tianjin Institutes of Health Science, Tianjin 301600, China.
iScience. 2024 Feb 23;27(4):109315. doi: 10.1016/j.isci.2024.109315. eCollection 2024 Apr 19.
As the only cell type responsible for oxygen delivery, erythrocytes play a crucial role in supplying oxygen to hypoxic tissues, ensuring their normal functions. Hypoxia commonly occurs under physiological or pathological conditions, and understanding how erythrocytes adapt to hypoxia is fundamental for exploring the mechanisms of hypoxic diseases. Additionally, investigating acute and chronic mountain sickness caused by plateaus, which are naturally hypoxic environments, will aid in the study of hypoxic diseases. In recent years, increasingly developed proteomics and metabolomics technologies have become powerful tools for studying mature enucleated erythrocytes, which has significantly contributed to clarifying how hypoxia affects erythrocytes. The aim of this article is to summarize the composition of the cytoskeleton and cytoplasmic proteins of hypoxia-altered erythrocytes and explore the impact of hypoxia on their essential functions. Furthermore, we discuss the role of microRNAs in the adaptation of erythrocytes to hypoxia, providing new perspectives on hypoxia-related diseases.
作为唯一负责氧气输送的细胞类型，红细胞在向缺氧组织供应氧气、确保其正常功能方面发挥着关键作用。缺氧通常发生在生理或病理条件下，了解红细胞如何适应缺氧是探索缺氧性疾病机制的基础。此外，研究高原这种自然缺氧环境所导致的急性和慢性高山病，将有助于缺氧性疾病的研究。近年来，日益发达的蛋白质组学和代谢组学技术已成为研究成熟无核红细胞的有力工具，这对阐明缺氧如何影响红细胞有显著贡献。本文旨在总结缺氧改变的红细胞的细胞骨架和细胞质蛋白组成，并探讨缺氧对其基本功能的影响。此外，我们讨论了微小RNA在红细胞适应缺氧中的作用，为缺氧相关疾病提供了新的视角。
