[成人斯蒂尔病与墨西哥人群中性粒细胞-淋巴细胞比值。病例系列报告]

[Adult-onset Still's disease and the neutrophil-lymphocyte index in the Mexican population. A case series report].

作者信息

Barrientos-Flores Corazón Jesús, Noyola-García Maura E, Albarrán-Sánchez Alejandra, Torres-Araujo Laura Victoria, Cano-Ortega Yisela, Alberti-Minutti Paolo, Anda-Garay Juan Carlos

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Medicina Interna, Ciudad de México, México.

出版信息

Rev Alerg Mex. 2020 Oct-Dec;67(4):413-420. doi: 10.29262/ram.v67i4.811.

DOI:10.29262/ram.v67i4.811

PMID:33631909

Abstract

BACKGROUND

In Mexico, adult-onset Still's disease (AOSD) is one of the causes of fever of unknown origin (FUO). The aim of this study is to describe a series of AOSD cases from a FUO cohort in order to know the clinical and biochemical characteristics of the cases, as well as to describe the neutrophil-lymphocyte index (NLI), which is a clinical marker of inflammation in autoimmune diseases.

CASE REPORT

An observational study of 24 cases with AOSD; 72 % of them were women, the median age was 43 years (IQR 37.7-59.7), and the most frequent manifestations were classic rash (84 %) and arthralgia (100 %). All of them had tested negative for rheumatoid factor, antinuclear antibodies, and hyperferritinemia; 83 % had NLI > 3.08. The most used treatment was the combination of methotrexate with corticosteroids; seven patients required biological therapy, and one of them presented a hypersensitivity reaction.

CONCLUSION

When there's FUO, the existence of AOSD should be suspected; also in the presence of rash, arthralgia, hyperferritinemia, and NLI > 3.08.

摘要

背景

在墨西哥，成人斯蒂尔病（AOSD）是不明原因发热（FUO）的病因之一。本研究的目的是描述一组来自FUO队列的AOSD病例，以了解这些病例的临床和生化特征，并描述中性粒细胞与淋巴细胞比值（NLI），其是自身免疫性疾病炎症的临床标志物。

病例报告

一项对24例AOSD病例的观察性研究；其中72%为女性，中位年龄为43岁（四分位间距37.7 - 59.7），最常见的表现为典型皮疹（84%）和关节痛（100%）。所有患者类风湿因子、抗核抗体检测均为阴性，且无高铁蛋白血症；83%的患者NLI > 3.08。最常用的治疗方法是甲氨蝶呤与皮质类固醇联合使用；7例患者需要生物治疗，其中1例出现过敏反应。