Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Cephalalgia. 2021 Aug;41(9):991-1003. doi: 10.1177/0333102421997850. Epub 2021 Feb 25.
To observe the prevalence and characteristics of premonitory symptoms in Chinese migraineurs and explore their associations with migraine-related factors.
Migraineurs who visited a tertiary headache clinic and one of nine neurology clinics between May 2014 and November 2019 were studied.
Among the 4821 patients meeting the migraine criteria (International Classification of Headache Disorders, 3rd edition), 1038 (21.5%) patients experienced at least one premonitory symptom. The most common premonitory symptoms were neck stiffness, dizziness, yawning and drowsiness. The logistic regression analysis demonstrated that aura, photophobia, aggravation by routine physical activity, triggers, family history, depression, coffee consumption and physical exercise were associated with an increased probability of experiencing premonitory symptoms ( ≤ 0.001). The premonitory symptoms of migraine with and without aura differ in prevalence and most common symptoms. The cluster analysis revealed pairwise clustering of the following premonitory symptoms: Photophobia/phonophobia, concentration change/dysesthesia, loquacity/overactivity, yawning/drowsiness, fatigue/dizziness, and mood change/irritability. The correlation analysis of triggers and premonitory symptoms revealed that temperature change, environment change, sleep disorder, activity and stress were related to multiple premonitory symptoms, and that food, light, menstruation, alcohol and odor were related to special premonitory symptoms ( ≤ 0.001).
The prevalence of premonitory symptoms among migraineurs in China is 21.5%. Some factors influence the probability of experiencing premonitory symptoms. Paired premonitory symptoms in the clustering analysis may share similar origins. Certain triggers associated with multiple premonitory symptoms may induce brain dysfunction; however, other triggers that overlap with corresponding special premonitory symptoms may be premonitory symptoms or a form of premonitory symptom.
观察中国偏头痛患者先兆症状的患病率和特征，并探讨其与偏头痛相关因素的关系。
研究对象为 2014 年 5 月至 2019 年 11 月期间在一家三级头痛诊所和九家神经病学诊所就诊的偏头痛患者。
在符合偏头痛标准的 4821 例患者中（国际头痛疾病分类，第 3 版），有 1038 例（21.5%）患者至少经历过一种先兆症状。最常见的先兆症状包括颈部僵硬、头晕、打哈欠和困倦。Logistic 回归分析表明，先兆、畏光、日常体力活动加重、诱因、家族史、抑郁、咖啡摄入和体育锻炼与出现先兆症状的概率增加有关（ ≤ 0.001）。有先兆和无先兆偏头痛的先兆症状在患病率和最常见症状方面存在差异。聚类分析显示以下先兆症状呈两两聚类：畏光/恐声、注意力改变/感觉异常、多话/多动、打哈欠/困倦、疲劳/头晕、情绪改变/易怒。诱因与先兆症状的相关分析显示，温度变化、环境变化、睡眠障碍、活动和压力与多种先兆症状有关，而食物、光线、月经、酒精和气味与特殊先兆症状有关（ ≤ 0.001）。
中国偏头痛患者先兆症状的患病率为 21.5%。一些因素影响出现先兆症状的概率。聚类分析中的成对先兆症状可能具有相似的起源。与多种先兆症状相关的某些诱因可能会引起大脑功能障碍；然而，与相应特殊先兆症状重叠的其他诱因可能是先兆症状或先兆症状的一种形式。
