Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030,China.
Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Ave 1095, Wuhan 430030,China.
Curr Neuropharmacol. 2022;20(1):223-253. doi: 10.2174/1570159X19666210225152728.
Great progress has been made in specifically identifying the central neural circuits (CNCs) of the core body temperature (Tcore), sleep-wakefulness states (SWs), and general anesthesia states (GAs), mainly utilizing optogenetic or chemogenetic manipulations. We summarize the neuronal populations and neural pathways of these three CNCs, which gives evidence for the orchestration within these three CNCs, and the integrative regulation of these three CNCs by different environmental light signals. We also outline some transient receptor potential (TRP) channels that function in the CNCs-Tcore and are modulated by some general anesthetics, which makes TRP channels possible targets for addressing the general-anestheticsinduced- hypothermia (GAIH). We suggest this review will provide new orientations for further consummating these CNCs and elucidating the central mechanisms of GAIH.
在特异性识别核心体温（Tcore）、睡眠-觉醒状态（SWs）和全身麻醉状态（GAs）的中枢神经回路（CNCs）方面取得了重大进展，主要利用光遗传学或化学遗传学操作。我们总结了这三个 CNC 的神经元群体和神经通路，为这三个 CNC 之间的协调以及不同环境光信号对这三个 CNC 的综合调节提供了证据。我们还概述了一些在 CNC-Tcore 中起作用的瞬时受体电位（TRP）通道，并受一些全身麻醉剂的调节，这使得 TRP 通道成为解决全身麻醉诱导性低体温（GAIH）的潜在靶点。我们建议，这篇综述将为进一步完善这些 CNC 和阐明 GAIH 的中枢机制提供新的方向。
Zotero 插件
