Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Curr Neuropharmacol. 2022;20(1):72-84. doi: 10.2174/1570159X19666211214144639.
General anesthesia has been successfully used in clinics for over 170 years, but its mechanisms of effect remain unclear. Behaviorally, general anesthesia is similar to sleep as it produces a reversible transition between wakefulness and the state of being unaware of one's surroundings. A discussion regarding the common circuits of sleep and general anesthesia has been ongoing as an increasing number of sleep-arousal regulatory nuclei are reported to participate in the consciousness shift occurring during general anesthesia. Recently, with progress in research technology, both positive and negative evidence for overlapping neural circuits between sleep and general anesthesia has emerged. This article provides a review of the latest evidence on the neural substrates for sleep and general anesthesia regulation by comparing the roles of pivotal nuclei in sleep and anesthesia.
全身麻醉在临床中已成功应用了 170 多年，但作用机制仍不清楚。从行为上看，全身麻醉类似于睡眠，因为它会在清醒和对周围环境失去意识之间产生可逆的转变。随着越来越多的睡眠觉醒调节核被报道参与全身麻醉过程中发生的意识转变，关于睡眠和全身麻醉共同回路的讨论一直在进行。最近，随着研究技术的进步，睡眠和全身麻醉之间存在重叠神经回路的正反两方面证据都出现了。本文通过比较睡眠和麻醉中关键核团的作用，综述了睡眠和全身麻醉调节的神经基础的最新证据。
