Ali Maqsood, Payne Samantha L
Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea.
Department of Biomedical Engineering, School of Engineering, Tufts University, Medford, MA, 02155, USA.
Biomater Res. 2021 Feb 25;25(1):5. doi: 10.1186/s40824-021-00206-w.
Chronic liver disease and cirrhosis is a widespread and untreatable condition that leads to lifelong impairment and eventual death. The scarcity of liver transplantation options requires the development of new strategies to attenuate disease progression and reestablish liver function by promoting regeneration. Biomaterials are becoming an increasingly promising option to both culture and deliver cells to support in vivo viability and long-term function. There is a wide variety of both natural and synthetic biomaterials that are becoming established as delivery vehicles with their own unique advantages and disadvantages for liver regeneration. We review the latest developments in cell transplantation strategies to promote liver regeneration, with a focus on the use of both natural and synthetic biomaterials for cell culture and delivery. We conclude that future work will need to refine the use of these biomaterials and combine them with novel strategies that recapitulate liver organization and function in order to translate this strategy to clinical use.
慢性肝病和肝硬化是一种广泛存在且无法治愈的疾病，会导致终身损伤并最终死亡。肝移植选择的稀缺性要求开发新的策略，通过促进再生来减缓疾病进展并重建肝功能。生物材料正成为培养和递送细胞以支持体内生存能力和长期功能的越来越有前景的选择。有各种各样的天然和合成生物材料正作为递送载体得到认可，它们在肝再生方面各有独特的优缺点。我们综述了促进肝再生的细胞移植策略的最新进展，重点关注天然和合成生物材料在细胞培养和递送中的应用。我们得出结论，未来的工作需要优化这些生物材料的使用，并将它们与重现肝脏组织结构和功能的新策略相结合，以便将该策略转化为临床应用。
