具核梭杆菌与结直肠癌的关联：一项系统评价和荟萃分析。
The association between Fusobacterium nucleatum and cancer colorectal: a systematic review and meta-analysis.
作者信息
Villar-Ortega Paola, Expósito-Ruiz Manuela, Gutiérrez-Soto Miguel, Ruiz-Cabello Jiménez Miguel, Navarro-Marí José María, Gutiérrez-Fernández José
机构信息
Departamento de Microbiología, Universidad de Granada-Instituto de Investigación BioSanitaria-ibs-Granada, Granada, España.
Departamento de Bioestadística de FIBAO. Hospital Universitario Virgen de las Nieves-Instituto de Investigación BioSanitaria-ibs-Granada, Granada, España.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Feb 22. doi: 10.1016/j.eimc.2021.01.005.
INTRODUCTION
The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.
OBJECTIVE
To review studies that address the association between F. nucleatum and CRC.
METHODS
The MEDLINE PubMed database was searched using the terms «colorectal cancer» and «Fusobacterium nucleatum», retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.
RESULTS
The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumor tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95% CI: 2.359-4.462).
CONCLUSION
There is a more frequent presence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.
引言
尽管遗传和环境因素与结直肠癌（CRC）的病因有关，但其确切病因尚不清楚。与具核梭杆菌的可能关联可能为早期诊断提供机会。
目的
综述探讨具核梭杆菌与结直肠癌之间关联的研究。
方法
使用“结直肠癌”和“具核梭杆菌”检索MEDLINE PubMed数据库，检索截至2020年1月1日发表的文献。使用Stata软件进行荟萃分析。
结果
系统评价纳入57篇文章。荟萃分析结果表明，与健康组织对照样本相比，具核梭杆菌在结直肠癌肿瘤组织样本中的出现频率更高，优势比为4.558（95%CI：3.312 - 6.272）；与结直肠腺瘤对照样本相比，优势比为3.244（95%CI：2.359 - 4.462）。
结论
具核梭杆菌在结直肠癌中出现频率更高。然而仍需进一步研究来验证这种关系。
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