Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Korean J Gastroenterol. 2021 Feb 25;77(2):84-87. doi: 10.4166/kjg.2020.154.
Colorectal perineuriomas are benign mucosal-based mesenchymal tumors composed of perineurial cells and show serrated or hyperplastic crypts in epithelium on histopathological evaluation. Most perineuriomas are usually presented as sessile polyps and often as subepithelial tumors. In this case, colonoscopy revealed a rectal subepithelial tumor (measuring approximately 7 mm) with yellowish- colored normal mucosa. A rectal neuroendocrine tumor was suspected, and cap-assisted endoscopic mucosal resection was performed. Histopathological examination of the resected specimen revealed bland spindle cells showing immunopositivity for CD34. The patient was finally diagnosed with rectal perineurioma.
直肠周围神经鞘瘤是一种良性黏膜基性间叶肿瘤，由周围神经鞘细胞组成，组织病理学评估可见锯齿状或增生性隐窝位于上皮内。大多数周围神经鞘瘤通常表现为无蒂息肉，常为黏膜下肿瘤。本例中，结肠镜检查发现直肠黏膜下肿瘤（约 7mm），表面有淡黄色正常黏膜。考虑为直肠神经内分泌肿瘤，行帽式辅助内镜黏膜切除术。切除标本的组织病理学检查显示为温和的梭形细胞，免疫组化 CD34 阳性。最终诊断为直肠周围神经鞘瘤。
