Maurer R, Tanner A, Honegger H P, Schmid U, Schmid L
Institut für Pathologie und medizinisch-onkologischer Dienst, Stadtspital Triemli, Zürich.
Schweiz Med Wochenschr. 1988 Mar 12;118(10):354-7.
On the basis of two personal observations and of 18 published cases, a review of primary non-Hodgkin lymphoma originating in the skeletal muscle is presented. The disease mainly affects persons in the seventh decade. Ninety-five percent of the tumors occur in the extremities, with 75% in the lower extremities. Most lymphomas were of low grade malignancy, with intermediate and high grade tumors accounting for 45% of cases. Reliable differentiation of NHL from other small round cell tumors of the soft tissues, such as rhabdomyosarcoma or Ewing sarcoma, and from metastatic carcinoma, is mandatory for therapeutic purposes. Diagnosis can be established by light microscopy alone in most patients. In doubtful cases immunohistochemistry may be required.
基于两项个人观察以及18例已发表的病例，本文对起源于骨骼肌的原发性非霍奇金淋巴瘤进行了综述。该疾病主要影响七十岁左右的人群。95%的肿瘤发生在四肢，其中75%发生在下肢。大多数淋巴瘤为低级别恶性，中高级别肿瘤占病例的45%。为了治疗目的，必须将非霍奇金淋巴瘤与其他软组织小圆细胞肿瘤，如横纹肌肉瘤或尤因肉瘤，以及转移性癌进行可靠区分。大多数患者仅通过光学显微镜检查即可确诊。在疑难病例中，可能需要进行免疫组织化学检查。
