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一种新的参数比 AHI 更能评估阻塞性睡眠呼吸暂停患者的夜间低氧血症和日间嗜睡。

A novel parameter is better than the AHI to assess nocturnal hypoxaemia and excessive daytime sleepiness in obstructive sleep apnoea.

机构信息

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.

出版信息

Sci Rep. 2021 Feb 25;11(1):4702. doi: 10.1038/s41598-021-84239-0.

DOI:10.1038/s41598-021-84239-0
PMID:33633338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7907378/
Abstract

To evaluate whether the percentage of total sleep time spent with apnoea and hypopnoea duration time (AHT%) is better than the apnoea-hypopnoea index (AHI) for the assessment of nocturnal hypoxaemia and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnoea (OSA). Patients with suspected OSA were enrolled. Polysomnography, Epworth Sleepiness Scale, self-administered surveys and anthropometric measures were performed. The efficiency of AHT% and the AHI was evaluated for nocturnal hypoxaemia and EDS. A total of 160 eligible participants were analysed. The median AHT% in normal, mild, moderate and severe OSA patients was significantly different in the four-group patients with OSA. Spearman rank correlations analysis found that the associations were stronger between AHT% with percentage of total sleep time and O saturation of < 90% and minimum nocturnal oxygen saturation than these parameters with the AHI. AHT% had a greater area under the curve than the AHI for predicting EDS in patients with OSA. AHT% was significantly higher in the EDS group. We present a novel parameter, AHT%, to evaluate nocturnal hypoxaemia and EDS in OSA patients. AHT% partially compensates for the shortcomings of the AHI. AHT% is better than the AHI for assessing nocturnal hypoxaemia and EDS. AHT% reflects different clinical characteristics associated with OSA from a new perspective.

摘要

评估阻塞性睡眠呼吸暂停(OSA)患者的总睡眠时间中伴呼吸暂停和低通气时间的百分比(AHT%)是否优于呼吸暂停低通气指数(AHI),以评估夜间低氧血症和日间嗜睡(EDS)。

纳入疑似 OSA 的患者。进行多导睡眠图、Epworth 嗜睡量表、自我管理调查和人体测量学测量。评估 AHT%和 AHI 对夜间低氧血症和 EDS 的效率。

共分析了 160 名符合条件的参与者。在四组 OSA 患者中,正常、轻度、中度和重度 OSA 患者的 AHT%中位数存在显著差异。Spearman 秩相关分析发现,AHT%与总睡眠时间和 O 饱和度<90%以及最小夜间氧饱和度的百分比之间的相关性强于与 AHI 的相关性。AHT%预测 OSA 患者 EDS 的曲线下面积大于 AHI。在 EDS 组中,AHT%明显更高。

我们提出了一个新的参数 AHT%,以评估 OSA 患者的夜间低氧血症和 EDS。AHT%部分弥补了 AHI 的不足。AHT%优于 AHI 评估夜间低氧血症和 EDS。AHT%从新的角度反映了与 OSA 相关的不同临床特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bae/7907378/60c5bdfaa06a/41598_2021_84239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bae/7907378/82e0d134044f/41598_2021_84239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bae/7907378/60c5bdfaa06a/41598_2021_84239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bae/7907378/82e0d134044f/41598_2021_84239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bae/7907378/60c5bdfaa06a/41598_2021_84239_Fig2_HTML.jpg

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