Berisha Destiny E, Rizvi Batool, Chappel-Farley Miranda G, Tustison Nicholas, Taylor Lisa, Dave Abhishek, Sattari Negin S, Chen Ivy Y, Lui Kitty K, Janecek John C, Keator David, Neikrug Ariel B, Benca Ruth M, Yassa Michael A, Mander Bryce A
Department of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine CA, 92697, USA.
bioRxiv. 2024 Jan 28:2024.01.28.577469. doi: 10.1101/2024.01.28.577469.
Obstructive sleep apnea (OSA) is common in older adults and is associated with medial temporal lobe (MTL) degeneration and memory decline in aging and Alzheimer's disease (AD). However, the underlying mechanisms linking OSA to MTL degeneration and impaired memory remains unclear. By combining magnetic resonance imaging (MRI) assessments of cerebrovascular pathology and MTL structure with clinical polysomnography and assessment of overnight emotional memory retention in older adults at risk for AD, cerebrovascular pathology in fronto-parietal brain regions was shown to statistically mediate the relationship between OSA-related hypoxemia, particularly during rapid eye movement (REM) sleep, and entorhinal cortical thickness. Reduced entorhinal cortical thickness was, in turn, associated with impaired overnight retention in mnemonic discrimination ability across emotional valences for high similarity lures. These findings identify cerebrovascular pathology as a contributing mechanism linking hypoxemia to MTL degeneration and impaired sleep-dependent memory in older adults.
阻塞性睡眠呼吸暂停（OSA）在老年人中很常见，并且与内侧颞叶（MTL）退化以及衰老和阿尔茨海默病（AD）中的记忆衰退有关。然而，将OSA与MTL退化和记忆受损联系起来的潜在机制仍不清楚。通过将脑血管病理学和MTL结构的磁共振成像（MRI）评估与临床多导睡眠图以及对有AD风险的老年人的夜间情绪记忆保持情况的评估相结合，结果显示，额顶叶脑区的脑血管病理学在统计学上介导了OSA相关低氧血症（尤其是在快速眼动睡眠期间）与内嗅皮质厚度之间的关系。反过来，内嗅皮质厚度的减少与高相似性诱饵在不同情绪效价的记忆辨别能力方面的夜间保持受损有关。这些发现确定脑血管病理学是将低氧血症与老年人MTL退化和睡眠依赖性记忆受损联系起来的一个促成机制。
