Shao Bo-Zong, Yao Yi, Zhai Jun-Shan, Zhu Jian-Hua, Li Jin-Ping, Wu Kai
The 8th Medical Center of General Hospital of the Chinese People's Liberation Army, Beijing, China.
Front Physiol. 2021 Feb 3;12:621132. doi: 10.3389/fphys.2021.621132. eCollection 2021.
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn's disease (CD). The abnormality of inflammatory and immune responses in the intestine contributes to the pathogenesis and progression of IBD. Autophagy is a vital catabolic process in cells. Recent studies report that autophagy is highly involved in various kinds of diseases, especially inflammation-related diseases, such as IBD. In this review, the biological characteristics of autophagy and its role in IBD will be described and discussed based on recent literature. In addition, several therapies for IBD through modulating the inflammasome and intestinal microbiota taking advantage of autophagy regulation will be introduced. We aim to bring new insight in the exploration of mechanisms for IBD and development of novel therapeutic strategies against IBD.
炎症性肠病（IBD）是一种特发性肠道炎症性疾病，包括溃疡性结肠炎（UC）和克罗恩病（CD）。肠道炎症和免疫反应异常促成了IBD的发病机制和进展。自噬是细胞中一个重要的分解代谢过程。最近的研究报告称，自噬高度参与各种疾病，尤其是炎症相关疾病，如IBD。在本综述中，将基于近期文献描述和讨论自噬的生物学特性及其在IBD中的作用。此外，还将介绍几种通过利用自噬调节来调节炎性小体和肠道微生物群的IBD治疗方法。我们旨在为IBD发病机制的探索和针对IBD的新型治疗策略的开发带来新的见解。
