中国儿童基因多态性与神经母细胞瘤易感性之间的关联。
Associations between gene polymorphisms and neuroblastoma susceptibility in Chinese children.
作者信息
Tang Jue, Lu Hongting, Yang Zhonghua, Li Le, Li Li, Zhang Jiao, Cheng Jiwen, Li Yong, Li Suhong, Zhou Haixia, He Jing, Liu Wei
机构信息
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
出版信息
Transl Pediatr. 2021 Jan;10(1):146-152. doi: 10.21037/tp-20-168.
BACKGROUND
Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma.
METHODS
To explore the association between three polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) and neuroblastoma susceptibility in Chinese populations, we performed this case-control study including 898 neuroblastoma cases and 1,734 controls. We genotyped these potentially functional single nucleotide polymorphisms (SNPs) by TaqMan assays. The odds ratios (ORs) and 95% confidence intervals (CIs) by logistic regression models were used to assess the relationship between SNPs and the risk of neuroblastoma.
RESULTS
No significant associations were observed in the overall analysis between any of the three polymorphisms and the risk of neuroblastoma. However, in the age ≤18 months subgroup, we found that the rs1853259 AG/GG genotype exerted protective effects against neuroblastoma (adjusted OR =0.77, 95% CI: 0.59-0.998, P=0.048), whereas the presence of 1-2 combined risk genotypes significantly increased the risk of neuroblastoma (adjusted OR =1.32, 95% CI: 1.02-1.71, P=0.036).
CONCLUSIONS
gene polymorphisms only have a weak impact on the risk of neuroblastoma in the Chinese children. Further case-control studies, preferable on larger sample sizes, are needed to validate our results.
背景
既往研究表明WTAP与多种癌症相关。最近，有报道称WTAP是神经母细胞瘤患者的独立预后因素。
方法
为探究三种多态性（rs9457712 G>A、rs1853259 A>G和rs7766006 G>T）与中国人群神经母细胞瘤易感性之间的关联，我们开展了这项病例对照研究，纳入898例神经母细胞瘤病例和1734例对照。我们采用TaqMan分析法对这些具有潜在功能的单核苷酸多态性（SNP）进行基因分型。通过逻辑回归模型计算比值比（OR）和95%置信区间（CI），以评估SNP与神经母细胞瘤风险之间的关系。
结果
在整体分析中，未观察到这三种多态性中的任何一种与神经母细胞瘤风险之间存在显著关联。然而，在年龄≤18个月的亚组中，我们发现rs1853259 AG/GG基因型对神经母细胞瘤具有保护作用（校正OR =0.77，95%CI：0.59 - 0.998，P =0.048），而存在1 - 2种合并风险基因型则显著增加神经母细胞瘤风险（校正OR =1.32，95%CI：1.02 - 1.71，P =0.036）。
结论
基因多态性对中国儿童神经母细胞瘤风险的影响较弱。需要进一步开展病例对照研究，最好是更大样本量的研究，以验证我们的结果。
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