Hegde Anisha, Denburg Michelle R, Glenn Dorey A
Department of Pediatrics, University of North Carolina Hospitals, Chapel Hill, NC, United States.
Division of Nephrology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Front Pediatr. 2021 Feb 9;8:635628. doi: 10.3389/fped.2020.635628. eCollection 2020.
Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.
急性肾损伤（AKI）已被证实会对多种身体系统产生有害影响。虽然急性肾损伤常伴有矿物质代谢失调，包括钙、磷、维生素D、甲状旁腺激素、成纤维细胞生长因子23和klotho的改变，但其对儿童和青少年骨骼系统的直接影响在很大程度上仍未得到充分研究。在这篇综述中，我们将讨论急性肾损伤中矿物质代谢失调的病理生理学及其对骨骼健康的潜在影响，包括将急性肾损伤与骨折风险相关联的数据。
