Tong Jieli, Low Randal Jun Bang, Joseph Francis Prabath, Ong Paul Jau Lueng, Lee Evelyn Min
Department of Cardiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
Eur Heart J Case Rep. 2020 Dec 7;4(6):1-7. doi: 10.1093/ehjcr/ytaa439. eCollection 2020 Dec.
Ventricular cystic masses are uncommon. Elucidating the cause is essential for early directed therapy and prevention of complications. We present two cases of ventricular cystic masses, one in each ventricle, after myocardial infarction (MI) and ventricular septal rupture (VSR), respectively.
Patient 1 is a 58-year-old male with left brachio-facial stroke and evolved anterior MI. A left ventricular (LV) cystic thrombus was seen on transthoracic echocardiogram (TTE) and cardiac magnetic resonance (CMR) imaging. He was started on anticoagulation with reduction in thrombus size 11 days later. Patient 2 is a 67-year-old male with evolved anterior MI, severe LV systolic dysfunction, and normal right ventricular (RV) function. He was readmitted two weeks later with fever, heart failure, bacteraemia, and septic pulmonary emboli. Transthoracic echocardiogram showed biventricular systolic dysfunction and a RV cystic mass associated with a partial VSR. He was treated with anticoagulation and antibiotics. Repeat TTE 5 weeks later revealed near resolution of the cystic mass and complete VSR. Cardiac magnetic resonance confirmed these findings and also showed a localized mid-septal transmural infarction at the VSR site. He underwent percutaneous coronary intervention to the left anterior descending and circumflex arteries, and percutaneous VSR closure with a muscular ventricular septal defect device later.
Our two cases demonstrate that ventricular thrombi can present as cystic masses after MI and VSRs. Infectious, vascular, or oncogenic causes should be considered in the appropriate clinical context. Early diagnosis and treatment is essential to prevent embolic complications, and secondary infection.
心室囊性肿物并不常见。明确病因对于早期针对性治疗及预防并发症至关重要。我们分别报告两例心室囊性肿物病例,一例位于心肌梗死(MI)后左心室,另一例位于室间隔破裂(VSR)后右心室。
病例1为一名58岁男性,有左侧臂面部卒中及陈旧性前壁心肌梗死。经胸超声心动图(TTE)及心脏磁共振(CMR)成像显示左心室(LV)有一个囊性血栓。给予抗凝治疗,11天后血栓尺寸缩小。病例2为一名67岁男性,有陈旧性前壁心肌梗死、严重左心室收缩功能障碍及正常右心室(RV)功能。两周后因发热、心力衰竭、菌血症及感染性肺栓塞再次入院。经胸超声心动图显示双心室收缩功能障碍及一个与部分室间隔破裂相关的右心室囊性肿物。给予抗凝及抗生素治疗。5周后复查TTE显示囊性肿物几乎消退且室间隔完全破裂。心脏磁共振证实了这些发现,还显示室间隔破裂部位有局限性中隔透壁梗死。他随后接受了左前降支和回旋支的经皮冠状动脉介入治疗,以及用肌肉型室间隔缺损封堵器进行经皮室间隔破裂封堵术。
我们的两例病例表明,心肌梗死和室间隔破裂后心室血栓可表现为囊性肿物。在适当的临床背景下应考虑感染、血管或肿瘤性病因。早期诊断和治疗对于预防栓塞并发症及继发感染至关重要。