Li Hu-Nian, Deng Na, Zhao Xu, Liu Jie, He Ting, Ding Xi-Wei
Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, No. 37 Chaoyang Middle Road, Shiyan, 442000, Hubei, China.
Children's Medical Center, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China.
Int J Clin Oncol. 2021 Jun;26(6):1022-1038. doi: 10.1007/s10147-021-01884-1. Epub 2021 Feb 25.
Hox transcript antisense intergenic RNA (HOTAIR), a lncRNA, functions as a critical regulator in cancer development. A plenty of case-control studies were conducted to assess the actual relationship of HOTAIR gene generic variants on cancer susceptibility, yet conflicting conclusions remain. Herein, we carried out this up-to-date meta-analysis to get a better understanding of such relationship by incorporating all eligible case-control studies.
Six widely investigated polymorphisms were included in this meta-analysis: rs920778, rs4759314, rs7958904, rs874945, rs1899663, and rs12826786. We retrieved relevant studies from databases PubMed, EMBASE, Medline, CNKI and Wanfang update to June 2020. We applied odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the relationship strengths.
Our findings indicate that rs920778, rs4759314, rs874945, rs12826786 polymorphism significantly increased with susceptibility to overall cancer. However, rs7958904, rs1899663 under any five genetic models could not impact susceptibility to overall cancer. Furthermore, altered cancer risk was detected when the data were stratified by cancer type, ethnicity, the source of controls, and HWE in all the SNPs.
These findings of the meta-analysis suggest that HOTAIR polymorphisms may predispose to cancer susceptibility.
Hox转录本反义基因间RNA（HOTAIR）作为一种长链非编码RNA，在癌症发展中起关键调节作用。大量病例对照研究旨在评估HOTAIR基因常见变异与癌症易感性之间的实际关系，但结论仍存在冲突。在此，我们进行了这项最新的荟萃分析，通过纳入所有符合条件的病例对照研究，以更好地理解这种关系。
本荟萃分析纳入了六个广泛研究的多态性：rs920778、rs4759314、rs7958904、rs874945、rs1899663和rs12826786。我们从PubMed、EMBASE、Medline、CNKI和万方数据库中检索了截至2020年6月的相关研究。我们应用比值比（OR）和95%置信区间（CI）来估计关系强度。
我们的研究结果表明，rs920778、rs4759314、rs874945、rs12826786多态性与总体癌症易感性显著增加有关。然而，rs7958904、rs1899663在任何五种遗传模型下均不影响总体癌症易感性。此外，当按癌症类型、种族、对照来源和所有单核苷酸多态性中的哈迪-温伯格平衡对数据进行分层时，发现癌症风险发生了改变。
荟萃分析的这些结果表明，HOTAIR多态性可能易导致癌症易感性。
