Li Jia, Liu Ruijuan, Tang Shifeng, Feng Fubin, Wang Xue, Qi Lingyu, Liu Cun, Yao Yan, Sun Changgang
School of Clinical Medicine, Weifang Medical University, Weifang, Shandong, China.
Oncology Department, Weifang Traditional Chinese Hospital, Weifang, Shandong, China.
J Cell Biochem. 2019 May;120(5):7056-7067. doi: 10.1002/jcb.27975. Epub 2018 Nov 28.
Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence of it is increasing. We performed a meta-analysis to clarify the relationship between lncRNA HOTAIR expression and BC, CC, and OC susceptibility. We thoroughly searched PubMed, Embase, and the Cochrane Library to obtain the relevant literature. We extracted data from case groups and control groups for each single-nucleotide polymorphism (SNP) (rs4759314, rs920778, rs189663, rs12826786, rs7958904, and rs874945) and compared the relationship between alleles, codominance models, dominant and invisible models and BC, CC, and OC susceptibility. Our study included 11 studies with a total of 5322 patients. There was a significant association between the rs4759314 polymorphism of HOTAIR and susceptibility to BC, CC, and OC (codominant model: AG/AA odds ratio [OR] = 1.13 [95% confidence intervals [CI], 1.00-1.29], GG/AA OR = 1.54 [95% CI, 1.06-2.23]; dominant model: GG + AG/AA OR = 1.16 [95% CI, 1.02-1.32]; and recessive model: GG/AA + AG OR = 1.51 [95% CI, 1.05-2.19]). The association between the expression of rs920778 and BC, CC, and OC susceptibility was not clear (alleles T/C: OR = 1.28 [95% CI, 0.87-1.89]; in codominant model: CT/CC OR = 1.10, [95% CI, 0.71-1.71], TT/CC OR = 1.29 [95% CI, 0.59-2.80]; dominant model: TC + TT/CC OR = 1.16, [95% CI, 0.73-1.86]; and recessive model: TT/TC + CC OR = 1.43, [95% CI, 0.83-2.47]). HOTAIR polymorphism rs1899663 was associated with BC, CC, and OC susceptibility to a certain extent, (alleles T/G OR = 0.90 [95% CI, 0.69-1.16]; in the codominant model: GT/GG OR = 0.81 [95% CI, 0.50-1.30], TT/GG OR = 1.04 [95% CI, 0.63-1.72]; dominant model: GT + TT/GG OR = 0.82 [95% CI, 0.52-1.29]; and recessive model: TT/GT + GG OR = 1.21 [95% CI, 0.76-1.94]). The rs12826786, rs7958904, and rs874945 polymorphisms were associated with a certain degree of BC, CC, and OC susceptibility, but they were not statistically significant. HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent. SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.
近期研究表明，长链非编码RNA（lncRNA）HOX转录反义基因间RNA（HOTAIR）多态性与癌症易感性相关。在各类癌症中，对女性健康构成最大威胁的是乳腺癌（BC）、宫颈癌（CC）和卵巢癌（OC），且其发病率呈上升趋势。我们进行了一项荟萃分析，以阐明lncRNA HOTAIR表达与BC、CC和OC易感性之间的关系。我们全面检索了PubMed、Embase和Cochrane图书馆以获取相关文献。我们从每个单核苷酸多态性（SNP）（rs4759314、rs920778、rs189663、rs12826786、rs7958904和rs874945）的病例组和对照组中提取数据，并比较了等位基因、共显性模型、显性和隐性模型与BC、CC和OC易感性之间的关系。我们的研究纳入了11项研究，共计5322例患者。HOTAIR的rs4759314多态性与BC、CC和OC易感性之间存在显著关联（共显性模型：AG/AA比值比[OR]=1.13[95%置信区间[CI]，1.00 - 1.29]，GG/AA OR = 1.54[95% CI，1.06 - 2.23]；显性模型：GG + AG/AA OR = 1.16[95% CI，1.02 - 1.32]；隐性模型：GG/AA + AG OR = 1.51[95% CI，1.05 - 2.19]）。rs920778表达与BC、CC和OC易感性之间的关联不明确（等位基因T/C：OR = 1.28[95% CI，0.87 - 1.89]；共显性模型：CT/CC OR = 1.10，[95% CI，0.71 - 1.71]，TT/CC OR = 1.29[95% CI，0.59 - 2.80]；显性模型：TC + TT/CC OR = 1.16，[95% CI，0.73 - 1.86]；隐性模型：TT/TC + CC OR = 1.43，[95% CI，0.83 - 2.47]）。HOTAIR多态性rs1899663在一定程度上与BC、CC和OC易感性相关，（等位基因T/G OR = 0.90[95% CI，0.69 - 1.16]；共显性模型：GT/GG OR = 0.81[95% CI，0.50 - 1.30]，TT/GG OR = 1.04[95% CI，0.63 - 1.72]；显性模型：GT + TT/GG OR = 0.82[95% CI，0.52 - 1.29]；隐性模型：TT/GT + GG OR = 1.21[95% CI，0.76 - 1.94]）。rs12826786、rs7958904和rs874945多态性与一定程度的BC、CC和OC易感性相关，但无统计学意义。HOTAIR rs4759314增加了部分患者对BC、CC和OC的易感性；rs029778和rs1899663在一定程度上也增加了易感性。SNP rs12826786、rs7958904和rs874945与患者对BC、CC和OC易感性的影响无关。
