Wang Hao, Wu Qi, Zhang Jian-Dong, Li Hai-Yan, Li Hong-Xi
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Analysis and Testing Center, Soochow University, Suzhou 215123, China.
Org Lett. 2021 Mar 19;23(6):2078-2083. doi: 10.1021/acs.orglett.1c00235. Epub 2021 Feb 26.
A photocatalyst- and transition-metal-free visible-light-induced cyclization of -halothiobenzanilides has been developed. Upon irradiation with visible light, substrates undergo dehalogenative cyclization to 2-aryl benzothiazoles with high efficiency and selectivity. This photocyclization exhibits a high tolerance to various functional groups, is applicable for the synthesis of 2-alkyl benzothiazoles, and is easy to set up for gram-scale reaction.
已开发出一种无光催化剂和过渡金属的可见光诱导的卤代硫代苯甲酰苯胺环化反应。在可见光照射下，底物高效且选择性地发生脱卤环化反应生成2-芳基苯并噻唑。这种光环化反应对各种官能团具有高度耐受性，适用于2-烷基苯并噻唑的合成，并且易于进行克级规模的反应设置。
