Jeffcott L B, Rossdale P D
Equine Vet J. 1977 Oct;9(4):208-15. doi: 10.1111/j.2042-3306.1977.tb04033.x.
The efficacy and safety of oxytocin, dexamethasone and prostaglandin, used alone or in combination as inducing agents, are discussed. It is contended that insufficient evidence exists to support the routine application of any of these methods in practice. Oxytocin has been the most widely used and it is claimed by some to be free from side effects. However, the synthetic prostaglandin analogue, fluprostenol, seems to pose the least risk to the foetus and dexamethasone appears to be either ineffective, or too dangerous to use at all. The main indications for induced foaling are managerial convenience or for research and teaching purposes. There are few clinical indications, although ventral rupture and cases of prolonged gestation have been mentioned by various workers. It is considered that foetal maturity is the pre-requisite before a decision to induce should be made in practice, and 3 criteria are essential: 1) a gestational length of greater than 320 days, 2) substantial mammary development, 3) the presence of colostrum in the mammae.
本文讨论了单独或联合使用催产素、地塞米松和前列腺素作为引产剂的疗效和安全性。有人认为，目前尚无足够证据支持在实践中常规应用这些方法中的任何一种。催产素是使用最广泛的，一些人声称它没有副作用。然而，合成前列腺素类似物氟前列醇似乎对胎儿的风险最小，而地塞米松似乎要么无效，要么使用起来太危险。引产的主要指征是管理方便或用于研究和教学目的。临床指征很少，尽管不同的研究者提到过腹侧破裂和妊娠期延长的病例。在实践中，决定引产之前，胎儿成熟被认为是先决条件，三个标准至关重要：1）妊娠期超过320天；2）乳房有明显发育；3）乳房中有初乳。
