Kelley R E, Pina I, Lee S C
Department of Neurology, University of Miami School of Medicine, Florida.
Stroke. 1988 Apr;19(4):443-6. doi: 10.1161/01.str.19.4.443.
We evaluated 36 patients with cerebral ischemia and mitral valve prolapse and compared them with 36 age-matched controls with cerebral ischemia who had similar attributes but who did not have mitral valve prolapse. Stepwise logistic regression analysis revealed an inverse relation between cerebral ischemia in the presence of mitral valve prolapse and hypertension, diabetes mellitus, occlusive cerebrovascular disease, and completed stroke at p less than 0.01. We also found, by correlation analysis, a negative correlation between both hypertension and diabetes mellitus versus mitral valve prolapse at p less than 0.05. Overall, 10 study patients compared with two control patients had no risk factors for cerebrovascular disease detected (chi 2 = 4.9, p less than 0.05). These data indicate that the association of mitral valve prolapse and cerebral ischemia is of special importance in patients who do not have other detected risk factors for cerebrovascular disease.
我们评估了36例患有脑缺血和二尖瓣脱垂的患者，并将他们与36例年龄匹配、患有脑缺血但没有二尖瓣脱垂且具有相似特征的对照者进行比较。逐步逻辑回归分析显示，存在二尖瓣脱垂时的脑缺血与高血压、糖尿病、闭塞性脑血管疾病以及已发生的中风之间呈负相关，p值小于0.01。通过相关性分析我们还发现，高血压和糖尿病与二尖瓣脱垂之间均呈负相关，p值小于0.05。总体而言，10例研究患者与2例对照患者相比未检测到脑血管疾病的危险因素（卡方 = 4.9，p值小于0.05）。这些数据表明，二尖瓣脱垂与脑缺血之间的关联在未检测到其他脑血管疾病危险因素的患者中具有特殊重要性。
