Department of Oncology and Hematology, Kaiser Permanente, Santa Clara, CA.
Division of Research, Kaiser Permanente, Santa Clara, CA.
Perm J. 2020 Dec;25:1-3. doi: 10.7812/TPP/20.093.
NUT carcinoma is an extremely rare disease and yet extremely aggressive with 2-year survival of only approximately 19% and median survival of 6 to 9 months.
We report here 2 successfully treated patients with durable complete remission (CR) after concurrent chemotherapy and radiation using 2 completely different chemotherapy regimens. One patient had extremely high tumor burden and obtained CR with ifosfamide and etoposide concurrently with radiation. One patient with low tumor burden obtained CR with carboplatin and paclitaxel concurrently with radiation. Interestingly, both patients had high PD-L1 expression in the tumor that may be associated with the favorable outcome.
Our experiences with these 2 successfully treated patients offer insight for the management of NUT carcinoma.
NUT 癌是一种极其罕见但极具侵袭性的疾病,2 年生存率仅约为 19%,中位生存期为 6 至 9 个月。
我们在此报告 2 例成功接受化疗和放疗联合治疗的患者,他们获得了持久的完全缓解(CR),使用了两种完全不同的化疗方案。一名患者肿瘤负荷极高,在接受异环磷酰胺和顺铂化疗的同时接受放疗,获得了 CR。另一名肿瘤负荷较低的患者接受了卡铂和紫杉醇化疗的同时接受放疗,获得了 CR。有趣的是,两名患者的肿瘤均有高 PD-L1 表达,这可能与良好的预后有关。
我们对这 2 例成功治疗的患者的经验为 NUT 癌的治疗管理提供了启示。