1stDepartment of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Warsaw, Poland.
PLoS One. 2021 Feb 26;16(2):e0247702. doi: 10.1371/journal.pone.0247702. eCollection 2021.
Cervical cancer is considered to be particularly amenable to prevention and highly treatable in its early stages. The real-time optoelectronic method of cervix examination seemed to be very promising in the detection of cervical squamous intraepithelial lesions and demonstrated relatively good efficacy. Although this method was introduced into clinics almost 10 years ago, it has not found its place in diagnostic schemes. At the moment, cytological smears and HPV detection with genotyping are still essential. TruScreen seems to be a slightly forgotten test. The aim of the study was to evaluate the efficacy and accuracy of TruScreen in detecting cervical pathology: CIN and cervical cancer confirmed with a histopathological diagnosis in comparison with other methods-cytology and colposcopy over four years of observations. The study was conducted on 130 women with abnormal Pap smear results. We can conclude that a real-time optoelectronic method like TruScreen can be useful as an effective initial cervical cancer screening in developing countries, possibly in combination with other methods. The combination of cytology and TruScreen examination may help clinicians to take decision about the next diagnostics steps (e.g. colposcopy) and contribute to better primary screening for cervical cancer.
宫颈癌被认为特别适合预防,并且在早期阶段高度可治疗。宫颈检查的实时光电方法似乎在检测宫颈鳞状上皮内病变方面非常有前途,并且表现出相对较好的效果。尽管这种方法在大约 10 年前就已经引入临床,但它尚未在诊断方案中找到自己的位置。目前,细胞学涂片和 HPV 检测及基因分型仍然是必不可少的。TruScreen 似乎是一个被遗忘的检测方法。本研究的目的是评估 TruScreen 在检测宫颈病变(CIN 和经组织病理学诊断证实的宫颈癌)方面的功效和准确性,并将其与细胞学和阴道镜检查等其他方法进行比较,观察时间为四年。本研究共纳入 130 名巴氏涂片结果异常的女性。我们可以得出结论,像 TruScreen 这样的实时光电方法可作为发展中国家有效的宫颈癌初始筛查方法,可能与其他方法联合使用。细胞学和 TruScreen 检查的联合应用可能有助于临床医生决定下一步的诊断步骤(例如阴道镜检查),并有助于更好地进行宫颈癌的初级筛查。