Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.
Department of Dermatology, University of Rzeszow, Poland.
Adv Clin Exp Med. 2021 Feb;30(2):189-195. doi: 10.17219/acem/131750.
Palmoplantar pustulosis (PPP) is a chronic inflammatory disease with poorly understood pathogenesis. The disease has a chronic course with improvements and exacerbations. Due to palmoplantar location, PPP has a severely negative impact on patients' quality of life.
To identify demographic and environmental factors, concomitant diseases, medications, and bacterial factors which may affect the course of PPP.
A total of 51 patients suffering from PPP took part in the study. They were classified according to the Palmoplantar Pustulosis Psoriasis Area and Severity Index (ppPASI) into 3 groups due to the severity of the disease. Pack-year of smoking score was established as a quotient of packets smoked every 24 h and the years of being addicted. Diagnosis of metabolic syndrome was based on the IDF criteria from 2009. Chlamydia trachomatis was detected using enzyme-linked immunosorbent assay (ELISA) technique, Staphylococcus aureus by the culture swabs. Contact hypersensitivity was examined with the T.R.U.E. test.
Significantly high severity of PPP was observed in patients addicted to smoking with a high pack-year score (p = 0.03). Significantly lower intensity of PPP lesions was observed in patients treated with ibuprofen (p < 0.01). There was no correlation between severity of PPP skin lesions and comorbidities.
Addiction to cigarette smoking and a high pack-year score aggravates the course of PPP. Treatment with ibuprofen can improve the course of the disease.
掌跖脓疱病（PPP）是一种发病机制尚不清楚的慢性炎症性疾病。该病呈慢性病程，时有缓解和加重。由于掌跖部位置的原因，PPP 严重影响患者的生活质量。
明确可能影响 PPP 病程的人口统计学和环境因素、合并症、药物和细菌因素。
共有 51 名患有 PPP 的患者参与了这项研究。根据掌跖脓疱病银屑病面积和严重程度指数（ppPASI），根据疾病的严重程度将他们分为 3 组。吸烟包年评分是根据每 24 小时吸烟的包数和吸烟的年数计算得出的商数。代谢综合征的诊断基于 2009 年 IDF 标准。采用酶联免疫吸附试验（ELISA）技术检测沙眼衣原体，采用培养拭子检测金黄色葡萄球菌。使用 T.R.U.E. 测试检查接触性过敏。
吸烟成瘾且吸烟包年评分较高的患者 PPP 严重程度明显较高（p = 0.03）。接受布洛芬治疗的患者 PPP 病变的强度明显较低（p < 0.01）。PPP 皮肤病变的严重程度与合并症之间无相关性。
吸烟成瘾和高吸烟包年评分可加重 PPP 的病程。布洛芬治疗可改善疾病的病程。
