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急性精神病学样本中恐惧、痛苦和强迫症的共病结构。

The comorbidity structure of fear, distress and compulsive disorders in an acute psychiatric sample.

机构信息

Department of Psychiatry, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Center for OCD & Related Disorders (CORD), Massachusetts General Hospital, Boston, MA, United States.

Department of Psychology, Fordham University, Bronx, NY, United States.

出版信息

J Anxiety Disord. 2021 Apr;79:102370. doi: 10.1016/j.janxdis.2021.102370. Epub 2021 Feb 16.

Abstract

Body dysmorphic disorder (BDD) and obsessive-compulsive disorder (OCD), collectively referred to as compulsive disorders, have typically not been included in structural research on the internalizing spectrum due to low prevalence in community samples. The current study examined the higher-order structure of anxiety, depressive and compulsive disorders among patients in a psychiatric partial hospital program (N = 2,178). We applied confirmatory factor analysis to diagnostic data obtained at admission and compared several competing models of the comorbidity structure. A one-factor model accounted well for the co-occurrence of all the disorders. A two-factor model comprised of fear and distress factors, wherein compulsive disorders loaded on fear, also fit the data well. However, a very large factor correlation (r = 0.86) suggested limited discriminant validity of fear and distress in the sample. Alternate models that featured a distinct compulsivity factor were not viable owing to large correlations between fear and compulsive disorders. Overall, our findings indicate that a broad internalizing dimensions underlies not only anxiety and depression, but also compulsive disorders, in an acute psychiatric population. Future studies using symptom-level data are needed to replicate these results and determine the structure of internalizing disorders from the bottom up, starting with narrowly defined symptom components.

摘要

躯体变形障碍(BDD)和强迫症(OCD)通常被称为强迫障碍,由于在社区样本中的患病率较低,因此在关于内化谱的结构研究中通常不包括这些障碍。本研究在精神病院部分医院计划的患者中检查了焦虑症、抑郁症和强迫症的高阶结构(N=2178)。我们对入院时获得的诊断数据进行了验证性因素分析,并比较了几种共病结构的竞争模型。一个因素模型很好地解释了所有障碍的共同发生。一个由恐惧和痛苦因素组成的双因素模型,其中强迫症在恐惧上有负荷,也很好地符合数据。然而,由于恐惧和强迫症之间存在很大的相关性(r=0.86),表明在样本中恐惧和痛苦的辨别效度有限。由于恐惧和强迫症之间存在很大的相关性,因此具有独特强迫性因素的替代模型是不可行的。总体而言,我们的研究结果表明,在急性精神病患者中,不仅焦虑症和抑郁症,而且强迫症都存在广泛的内化维度。需要使用症状水平数据的未来研究来复制这些结果,并从狭窄定义的症状成分开始,从底层确定内化障碍的结构。

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