Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia.
Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia.
Kidney Int. 2021 Mar;99(3):539-542. doi: 10.1016/j.kint.2020.11.011.
Renal signaling networks downstream of FGF23 are not well delineated, but elucidating them may offer an opportunity to control target genes independent of FGF23 in states of dysregulated mineral metabolism. Ni et al. identify HBEGF as a paracrine/autocrine factor in the proximal tubules of mice that mimics the inductive effect of FGF23 on the vitamin D-catabolizing enzyme 24-hydroxylase through a common mitogen-activated protein kinase-dependent pathway. An understanding of how these findings relate to human disease is eagerly anticipated.
肾脏中 FGF23 下游的信号网络尚未完全阐明，但阐明这些信号网络可能为在矿物质代谢失调的情况下，提供一种不依赖于 FGF23 而控制靶基因的机会。Ni 等人鉴定出 HBEGF 是一种旁分泌/自分泌因子，它在小鼠的近端小管中模拟了 FGF23 通过共同的丝裂原活化蛋白激酶依赖性途径对维生素 D 代谢酶 24-羟化酶的诱导作用。人们急切地期待着了解这些发现与人类疾病的关系。
