移植后复发性膜性肾病：供体抗原和 HLA 共同定义风险。
Recurrent membranous nephropathy after transplantation: donor antigen and HLA converge in defining risk.
机构信息
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia.
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Pediatric Nephrology, Monash Health, Clayton, Victoria, Australia.
出版信息
Kidney Int. 2021 Mar;99(3):545-548. doi: 10.1016/j.kint.2020.10.044.
Membranous nephropathy, like many forms of glomerulonephritis, is an HLA-associated autoimmune disease that can recur in the transplanted kidney. In this issue of Kidney International, Berchtold and colleagues publish an intriguing and important paper on risk factors for recurrent post-transplant membranous nephropathy due to autoimmunity to PLA2R1. They found that the genetics of both the autoantigen and donor HLA are important determinants of the risk of recurrent disease in the graft.
膜性肾病与许多形式的肾小球肾炎一样，是一种 HLA 相关的自身免疫性疾病，可在移植肾脏中复发。在本期《国际肾脏杂志》上，Berchtold 及其同事发表了一篇关于 PLA2R1 自身免疫导致移植后膜性肾病复发的危险因素的有趣且重要的论文。他们发现，自身抗原和供体 HLA 的遗传因素都是移植物中疾病复发风险的重要决定因素。
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