肝转移灶放疗可恢复免疫治疗应答。

Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness.

机构信息

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

出版信息

Trends Immunol. 2021 Apr;42(4):275-277. doi: 10.1016/j.it.2021.02.007. Epub 2021 Feb 23.

DOI:10.1016/j.it.2021.02.007

PMID:33637449

Abstract

Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.

摘要

同种异体肝移植能使免疫系统耐受，防止来自同一供体的器官排斥。于等人最近的一篇文章表明，肝转移同样可以防止免疫治疗的小鼠和人类宿主中的肿瘤排斥。此外，辐射可以重新编程肝微环境，恢复全身肿瘤排斥。